| |
|
Cohort 1 |
Cohort 2 |
Cohort 3 |
| Polymorphisms |
Healthy Controls (n=200) |
DM(356) |
DNP (139) |
OR (95%CI) P |
DM (342) |
DNP (133) |
OR (95%CI) P |
DM (207) |
DNP (81) |
OR (95%CI) P |
T-786C
(rs 2070744)
|
TT=131 (0.66)
TC=67 (0.33)
CC=2 (0.01)
TC+CC=69 (0.34)
T=329 (0.82)
C=71 (0.18) |
TT=199 (0.56)
TC=121 (0.34)
CC=36
(0.10)
TC+CC=157 (0.44)
T=519 (0.73)
C=193 (0.27) |
TT=72
(0.52)
TC=50 (0.36)
CC=17
(0.12)
TC+CC=67 (0.48)\
T=194 (0.70)
C=84 (0.30) |
1.22 (0.76-1.89) 0.79
1.30 (0.65-2.90) 0.72
1.11 (0.70-1.90) 0.61
1.16 (0.86-1.58) 0.37 |
TT=171 (0.50)
TC=130 (0.38)
CC=41 (0.12)
TC+CC=166 (0.50)
T=472 (0.69)
C=212 (0.31) |
TT=66
(0.50)
TC=52 (0.39)
CC=15
(0.11)
TC+CC=67 (0.50)
T=184 (0.69)
C=82 (0.31) |
1.12 (0.80-1.55) 0.98
1.15 (0.66-1.90) 1.02
1.12 (0.81-1.55) 0.80
0.99 (0.73-1.35) 1 |
TT=107 (0.52)
TC=75 (0.36)
CC=25
(0.12)
TC+CC=100 (0.48)
T=289 (0.70)
C=125 (0.30) |
TT=40 (0.49)
TC=31 (0.39)
CC=10 (0.12)
TC+CC=41 (0.51)
T=111 (0.69)
C=51 (0.31) |
1.22 ( 0.85-1.45) 0.90
1.11 (0.62-1.98) 0.94
1.20 (0.83-1.61) 1.02
1.06 (0.72-1.57) 0.84 |
G894T
(rs 1799983) |
GG=102 (0.51)
GT=80 (0.40)
TT=18 (0.09)
GT+TT=98 (0.49)
G=284 (0.71)
T=116 (0.29) |
GG=156 (0.44)
GT=164 (0.46)
TT=36
(0.10)
GT+TT=200 (0.56)
G=476 (0.67)
T=236 (0.33) |
GG=65
(0.47)
GT=60
(0.43)
TT=14
(0.10)
GT+TT=74 (0.53)
G=190 (0.68)
T=88 (0.32) |
0.94 (0.59-1.60) 0.79
0.94 (0.42-2..22) 0.89
0.95 (0.59-1.52) 0.78
0.93 (0.69-1.26) 0.71 |
GG=157 (0.46)
GT=144 (0.42)
TT=41
(0.12)
GT+TT=185 (0.54)
G=458 (0.67)
T=226 (0.33) |
GG=63 (0.47)
GT=57
(0.43)
TT=13
(0.10)
GT+TT=70 (0.53)
G=183 (0.69)
T=83 (0.31) |
1.08 (0.72-1.52) 1.05
0.80 (0.41-1.52) 0.62
1.20 (0.77-1..48) 0.95
0.92 (0.68-1.25) 0.64 |
GG=97
(0.47)
GT=87 (0.42)
TT=23
(0.11)
GT+TT=110 (0.53)
G=281 (0.68)
T=133 (0.32) |
GG=39 (0.48)
GT=34
(0.42)
TT=8
(0.10)
GT+TT=42 (0.52)
G=112 (0.69)
T=50 (0.31) |
1.03 (0.75-1.51) 0.89
0.97 (0.42-1.51) 0.87
0.90 (0.71-.1.42) 0.95
0.94 (0.64-1.40) 0.84 |
| 27 VNTR |
bb=7 (0.03)
ba=49 (0.25)
aa=144 (0.72)
ba+aa=193 (0.97)
b=63 (0.16)
a=337 (0.84) |
bb=217 (0.61)
ba*=121
(0.34)
aa*=18
(0.05)
ba+aa*=139 (0.39)
b=555 (0.78)
a*=157(0.22) |
bb=61
(0.44)
ba*=63
(0.45)
aa*=15
(0.11)
ba+aa*=78 (0.56)
b=185 (0.67)
a*=93 (0.33) |
1.85 (1.22-2.81) 0.005
2.96 (1.41-3.22) 0.006
2.00 (1.34-2.97) 0.008
1.77 (1.31-2.41)
0.003 |
bb=202 (0.59)
ba*=121
(0.35)
aa*=21
(0.06)
ba+aa*=142 (0.41)
b=523 (0.76)
a*=161 (0.24) |
bb=59
(0.44)
ba*=57
(0.43)
aa*=17
(0.13)
ba+aa*=74
(0.56)
b=175 (0.66)
a*=91 (0.34) |
1.61 (1.05-2.47) 0.04
2.77 (1.37-3.59) 0.006
1.78 (1.19-2.67) 0.006
1.69 (1.24-2.30) 0.001 |
bb=117 (0.57)
ba*=75
(0.36)
aa*=14
(0.07)
ba+aa*=89 (0.41)
b=310 (0.75)
a*=104 (0.25) |
bb=37
(0.46)
ba*=33
(0.41)
aa*=11
(0.13)
ba+aa*=44 (0.54)
b=107 (0.66)
a*=55 (0.34) |
1.39 (1.07-2.42) 0.03
2.48 (1.84-3.92) 0.006
1.56 (1.10-2.61) 0.62
1.53 (1.13-2.27) 0.004 |
*P<0.05 P values for the model are adjusted for potential confounders which include age, gender, HbA1c, duration of diabetes, duration of hypertension, smoking, systolic
blood pressure, triglyceride levels, ACEI/ARB, serum creatinine and eGFR