Cohort 1 Cohort 2 Cohort 3
Haplotypea DNP (139) DM(356) OR (95%CI) P DNP (133)   DM (342) OR (95%CI) P DNP (81) DM (207) OR (95%CI) P
T-b-G 17 (0.12) 46 (0.13) Reference 15 (0.11) 44 (0.13) Reference 10 (0.12) 29 (0.14) Reference
T-b-T 18 (0.14) 53 (0.15) 1.09 (0.82-1.55) 0.88 16 (0.12) 48 (0.14) 0.92 (0.70-1.32) 0.88 11 (0.14) 33 (0.16) 0.99 (0.68-1.36) 0.22
C-b-G 13 (0.09) 39 (0.11) 1.23 (0.99-1.59) 0.21 15 (0.11) 44 (0.13) 1.13 (1.02-1.80) 0.12 8 (0.10) 25 (0.12) 1.25 (0.92-1.77) 0.31
T-a-G 13 (0.09) 39 (0.11) 0.69(0.30-1.37) 0.55 13 (0.10) 41 (0.12) 1.22 (0.79-1.54) 0.91 8 (0.10) 27 (0.13) 0.93 (0.55-1.34) 0.77
C-b-T 22 (0.16) 61 (0.17) 0.69 (0.35-1.44) 0.67 21 (0.17) 65 (0.19) 0.79 (0.44-1.14) 0.37 12 (0.15) 35 (0.17) 0.77 (0.42-1.11) 0.45
T-a-T 24 (0.17) 68 (0.19) 1.12 (0.88-1.81) 0.13 23 (0.17) 58 (0.17) 1.55 (1.21-1.92) 0.12 13 (0.16) 38 (0.18) 0.99 (0.59-1.55) 1.02
C-a-G* 17 (0.12) 25 (0.07) 1.55 (1.22-2.80) 0.01 15 (0.11) 21 (0.06) 1.37 (1.20-2.94) 0.01 10 (0.12) 10 (0.05) 1.65 (1.42-2.91) 0.01
C-a-T* 15 (0.11) 25 (0.07) 1.71 (1.31-2.96) 0.008 15 (0.11) 21 (0.06) 1.71 (1.47-2.98) 0.009 9 (0.11) 10 (0.05) 1.77 (1.57-2.94) 0.007
aOrder of SNPs in eNOS haplotypes: T-786C, a 27VNTR b and G894T. *P<0.05
Table 5: eNOS gene Haplotype Frequency Distribution (DM vs. DNP).