| 
      *Analysis by repeated measures ANOVA
        |  |  | Baseline |  | 3 months | 6 months |  
        | Variable | N | Mean ± SD | N** | Mean (CI) | p-value* | Mean (CI) | p-value* |  
        | Age (years) | 33 | 42.7 ±    12.3 |  |  |  |  |  |  
        | Height (cm) | 33 | 172 ± 1.0 |  |  |  |  |  |  
        | Weight (kg) | 33 | 118.1 ±    23.8 | 32 | -8.7
          (-10.6 to -6.7) | <0.001 | -11.1
          (-13.5 to -8.6) | <0.001 |  
        | BMI (kg/m2) | 33 | 40.0 ± 7.3 | 32 | -2.9
          (-3.6 to -2.3) | <0.001 | -3.8
          (-4.6 to -2.9) | <0.001 |  
        | WC (cm) | 33 | 124 ± 15.6 | 32 | -6.5
          (-7.8 to -5.1) | <0.001 | -10.8
          (-12.7 to -8.9) | <0.001 |  
        | Body fat (%) | 31 | 46.7 ± 6.8 | 29 | -4.3
          (-5.3 to -3.3) | <0.001 | -4.7
          (-5.9 to -3.5) | <0.001 |  
        | Fat mass (kg) | 31 | 54.1 ±    12.6 | 29 | -8.8
          (-10.5 to -7.1) | <0.001 | -10.2
          (-12.3 to -8.1) | <0.001 |  
        | Fasting glucose (mmol/L) | 33 | 5.0 ± 0.9 | 31 | -0.1
          (-0.5 to 0.3) | 0.648 | 0.6
          (0.3 to 0.8) | <0.001 |  
        | 2h glucose (mmol/L) | 33 | 8.2 ± 3.0 | 31 | -1.2
          (-2.2 to 0.2) | 0.017 | -0.8
          (-1.5 to 0.0) | 0.042 |  
        | SE (%) | 33 | 81.8 ± 6.9 | 27 | -1.7
          (-3.3 to -0.1) | 0.035 | -1.5
          (-3.3 to 0.3) | 0.095 |  
        | ESS | 33 | 3.4 ± 2.7 | 32 | -0.3 
          (-0.8 to 0.3) | 0.337 | -0.5
          (-1.1 to 0.1) | 0.078 |  
        | PA (min/day) | 33 | 69 ± 49 | 27 | 30
          (7 to 53) | 0.011 | 9
          (-8 to 26) | 0.273 |  **Number of subjects that had baseline, 3 and 6 months measurements for the analyzed variables in the repeated measures ANOVA
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