Baseline 1 month 3 months 6 months 12 months 24 months Control group Mean (95% CI) 2.33 (2.07-2.59) 3.04 (2.82-3.25) 2.61 (2.44-2.78) 2.61 (2.44-2.78) 2.61 (2.44-2.78) 2.61 (2.44-2.78) Variance 1.61 1.60 1.60 1.60 1.60 1.60 Intervention group Mean (95% CI) 2.33 (2.07-2.59) 3.04 (2.82-3.25) 2.61 (2.44-2.78) 2.61 (2.44-2.78) 2.61 (2.44-2.78) 2.61 (2.44-2.78) Variance 1.60 1.60 1.60 1.60 1.60 1.60 Intervention group Covariances (and correlations) Baseline   0.66 (0.41) 0.11 (0.07) 0.02 (0.01) 0.76 (0.48) 0.29 (0.18) 1 month 0.57 (0.36)   0.57 (0.36) 0.57 (0.36) 0.57 (0.36) 0.57 (0.36) 3 months 0.11 (0.07) 0.57 (0.36)   0.57 (0.36) 0.57 (0.36) 0.57 (0.36) 6 months 0.57 (0.36) 0.57 (0.36) 0.57 (0.36)   0.57 (0.36) 0.57 (0.36) Control group 12 months 0.57 (0.36) 0.57 (0.36) 0.57 (0.36) 0.57 (0.36)   0.71 (0.44) 24 months 0.57 (0.36) 0.57 (0.36) 0.57 (0.36) 0.57 (0.36) 0.97 (0.61)

Table 4(c): Population mean (95%CI), variances and covariances from the model with hypoglycaemic episodes as outcome from baseline to 24 months.