| Histological Feature |
Diet (n=5) |
Exercise (n=9) |
P Value DIWL vs EXτ |
| Pre |
Post |
P Value |
Pre |
Post |
P
Value |
| Steatosis |
|
|
|
|
|
|
|
% Hepatocytes affected
Score – no. of subjects
0 (<5%)
1 (5-33%)
2 (>33% - 66%)
3 (>66%)
No. pts with improvement - %
Pts with a reduction in score of ≥2* – no./total no. (%) |
73 ± 36
0
1
0
4
|
23 ± 32
1
3
0
1
80%
4/5(80)
|
0.04
0.08
|
71 ± 32
0
2
1
6
|
54 ± 36
0
3
1
5
22%
1/9(11) |
0.12
0.59
|
0.05
0.02
|
| Hepatocyte ballooning |
|
|
|
|
|
|
|
Score – no. of subjects
0 (None)
1 (Few)
2 (Many)
No. pts with improvement - % |
2
2
1 |
4
1
0
4/5(80) |
0.50 |
1
4
4 |
3
3
3
4/9(44) |
0.34 |
0.06
0.30 |
| Lobular inflammation |
|
|
|
|
|
|
|
Score – no. of subjects
0 (0 or 1 focus)
1 (2-4 foci per 200x field)
2 (>4 foci per 200x field)
No. pts with improvement - % |
2
1
2 |
4
1
0
5/5(100) |
0.17 |
0
5
4 |
1
4
4
2/9(22) |
0.77 |
0.005
0.02 |
| NAS |
|
|
|
|
|
|
|
Median (range)
Pts with a reduction in score of ≥2* – no./total no. (%) |
5 (1-7) |
2 (0-5)
4/5(80) |
0.05 |
5 (2-8) |
5 (1-7)
2/9(22) |
0.29 |
0.02
0.09 |
| Fibrosis |
|
|
|
|
|
|
|
Score – no. of subjects
0 (None)
1 (Perisinusoidal or periportal)
2 (Perisinusoidal and portal or periportal)
3 (Bridging fibrosis)
4 (Cirrhosis)
No. pts with improvement - %
Pts with a reduction in score of ≥2* – no./total no. (%) |
2
2
1
0
0 |
4
1
0
0
0
4/5(80)
4/5(80) |
0.50 |
3
2
2
2
0 |
5
1
0
1
2
6/9(67)
5/9(56) |
1.0 |
0.13
1.0
0.58 |
| NASH§ |
|
|
|
|
|
|
|
| Pts with resolution of NASH –no./total no. (%) |
|
2/3(67) |
|
|
2/8(25) |
|
0.49 |
* Reduction in score of ≥2 or <2 but normalised tissue or was normal at baseline and remained normal