Lifestyle  risk factors  
          (risk    factor B) | 
        No. Cases | 
        Person-years | 
        HR a (95% CI) 
          FHD  but not risk    factor B | 
        HR a (95% CI) 
          Risk factor B but not FHD | 
        HR a (95% CI) 
          FHD and  
          risk factor B | 
        SI 
          (95% CI) | 
        AP 
          (95% CI) | 
       
      
        | Overweight  (25 ≤ BMI<30) | 
        47 | 
        323,793 | 
        2.23 (1.00-4.99) | 
        1.38 (0.65-2.94) | 
        4.60 (2.32-9.10) | 
        2.23 (0.70-7.04) | 
        0.43 (0.03-0.83) | 
       
      
        | Obesity (30    ≤ BMI) | 
        48 | 
        90,072 | 
        2.16 (0.97-4.84) | 
        6.69 (3.25-13.77) | 
        11.68 (5.68-24.01) | 
        1.56 (0.81-3.01) | 
        0.33 (0.00-0.72) | 
       
      
        | WHR (at risk)b | 
        18 | 
        69,193 | 
        2.15 (0.86-5.35) | 
        1.84 (0.61-5.55) | 
        5.75 (2.24-14.74) | 
        2.39 (0.63-9.08) | 
        0.48 (0.01-0.95) | 
       
      
        | Physical inactivity  | 
        74 | 
        484,696 | 
        2.13 (1.31-3.45) | 
        1.28 (0.71-2.28) | 
        3.62 (2.13-6.14) | 
        1.85 (0.74-4.67) | 
        0.33 (0.00-0.71) | 
       
      
        | Non-regular alcohol consumption | 
        73 | 
        299,414 | 
        2.40 (1.33-4.33) | 
        1.32 (0.70-2.51) | 
        3.68 (2.02-6.70) | 
        1.56 (0.64-3.79) | 
        0.26 (0.00-0.69) | 
       
      
        | Low psychosocial well-being  | 
        22 | 
        80,490 | 
        1.58 (0.90-2.76) | 
        1.53 (0.69-3.42) | 
        5.03 (2.56-9.89) | 
        3.63 (0.86-15.25) | 
        0.58 (0.24-0.93) | 
       
     
      SI: Synergy Index; AP: Attributable Proportion 
      Total study population: N=49,712. 
      aAll combinations adjusted for age and sex; smoking, education, physical activity, and BMI (except the factor under analyses) 
    bResults from HUNT2 to HUNT3 (1995-2008) |