Lifestyle  risk factors
(risk factor B)
No. Cases Person-years HR a (95% CI)
FHD  but not risk factor B
HR a (95% CI)
Risk factor B but not FHD
HR a (95% CI)
FHD and
risk factor B
SI
(95% CI)
AP
(95% CI)
Overweight  (25 ≤ BMI<30) 47 323,793 2.23 (1.00-4.99) 1.38 (0.65-2.94) 4.60 (2.32-9.10) 2.23 (0.70-7.04) 0.43 (0.03-0.83)
Obesity (30 ≤ BMI) 48 90,072 2.16 (0.97-4.84) 6.69 (3.25-13.77) 11.68 (5.68-24.01) 1.56 (0.81-3.01) 0.33 (0.00-0.72)
WHR (at risk)b 18 69,193 2.15 (0.86-5.35) 1.84 (0.61-5.55) 5.75 (2.24-14.74) 2.39 (0.63-9.08) 0.48 (0.01-0.95)
Physical inactivity 74 484,696 2.13 (1.31-3.45) 1.28 (0.71-2.28) 3.62 (2.13-6.14) 1.85 (0.74-4.67) 0.33 (0.00-0.71)
Non-regular alcohol consumption 73 299,414 2.40 (1.33-4.33) 1.32 (0.70-2.51) 3.68 (2.02-6.70) 1.56 (0.64-3.79) 0.26 (0.00-0.69)
Low psychosocial well-being 22 80,490 1.58 (0.90-2.76) 1.53 (0.69-3.42) 5.03 (2.56-9.89) 3.63 (0.86-15.25) 0.58 (0.24-0.93)
SI: Synergy Index; AP: Attributable Proportion
Total study population: N=49,712.
aAll combinations adjusted for age and sex; smoking, education, physical activity, and BMI (except the factor under analyses)
bResults from HUNT2 to HUNT3 (1995-2008)
Table 2: Interaction effects on adult-onset autoimmune diabetes of Co-exposure to FHD and lifestyle risk factors (risk factor B).