Figure 11: Illustration of the role of SREBP in lipid production induction The ER membrane bound SREBP transcription factor is in an inactive form. It makes a complex with SCAP and together anchor to Insig protein of ER membrane. In high concentration of sterol this anchored junction is released and the SREBP-SCAP complex is transferred to the Golgi apparatus. Degradation of SREBP and release of its bHLH domain to the nucleus induces the process of lipid production.