| |
All patients (N=286791) |
<55 years N=37221 |
55-74 years N=153350 |
≥75 years N=96320 |
≤2 years (N=63061) |
3-5 years (N=101848) |
6-10 years (N=80369) |
>10 years (N=41513) |
| Sex, % of males |
53.7 |
65.9 |
57.1 |
43.5 |
57.9 |
54.8 |
52.0 |
47.9 |
| Age, mean years ± SD |
68.2 ± 11.4 |
48.3 ± 4.9 |
65.4 ± 5.5 |
80.3 ± 3.9 |
64.1 ± 12.4 |
67.8 ± 11.3 |
69.8± 10.4 |
72.4± 9.3 |
| Diabetes duration, mean years ± SD |
6.5 ± 5.1 |
4.3 ± 3.2 |
6.4 ± 4.7 |
7.7 ± 5.9 |
1.7 ± 0.7 |
4.6 ± 0.8 |
7.9 ± 1.4 |
16.0 ± 5.7 |
| HbA1c, mean, % ± SDa |
7.1 ± 1.5 |
7.5 ± 1.9 |
7.2 ± 1.4 |
7.0 ± 1.3 |
6.8 ± 1.4 |
7.1 ± 1.4 |
7.3 ± 1.4 |
7.5 ± 1.5 |
| HbA1c, mean, mmol/mol ± SDa |
54.6 ± 16.0 |
58.8 ± 20.3 |
54.9 ± 15.7 |
52.9 ± 14.2 |
50.9 ± 15.6 |
54.3 ± 15.8 |
56.3 ± 15.8 |
58.1 ± 16.0 |
| HbA1c≤ 7% (≤ 53 mmol/mol) (%)a |
56.1 |
49.3 |
55.2 |
60.0 |
69.6 |
57.4 |
50.8 |
43.8 |
| BMI, mean Kg/m2 ± SDb |
29.6 ± 5.0 |
30.7 ± 5.7 |
30.0 ± 5.0 |
28.6 ± 4.6 |
30.8 ± 5.1 |
29.7 ± 5.0 |
29.5 ± 5.0 |
29.1 ± 4.1 |
| Obesity (BMI ≥ 30 Kg/m2) (%)b |
45.4 |
53.4 |
48.0 |
38.1 |
48.9 |
46.3 |
43.9 |
40.9 |
| Current smoker |
15.6 |
36.8 |
16.7 |
5.8 |
20.7 |
16.5 |
13.6 |
10.3 |
Any macrovascular %
Coronary %
Cerebrovascular % |
17.4
11.9
6.7 |
6.4
4.2
1.6 |
16.3
10.5
5.0 |
26.2
15.2
10.8 |
13.1
7.9
4.6 |
17.3
10.6
6.2 |
20.5
12.7
7.2 |
25.0
15.3
9.1 |
| Retinopathy % |
5.8 |
3.4 |
6.0 |
6.4 |
1.9 |
4.6 |
6.7 |
13.0 |
| Nephropathy %c |
16.7 |
17.1 |
15.3 |
18.9 |
14.2 |
16.2 |
17.5 |
19.6 |
Renal Functiond
eGFR ≥ 60 mL/min/1.73 m2, %
eGFR 30-59 mL/min/1.73 m2, %
eGFR <30 mL/min/1.73 m2, % |
81.6
17.1
1.3 |
97.4
2.3
0.2 |
87.8
11.4
0.8 |
66.3
31.3
2.4 |
86.9
12.4
0.7 |
82.2
16.6
1.2 |
79.9
18.7
1.4 |
75.6
22.3
2.1 |
| Glycaemic-lowering step of treatment |
|
Lifestyle only (N= 69924) (%)
HbA1c, mean %
HbA1c, mean, mmol/mol ± SD
HbA1c≤ 7% (≤ 53 mmol/mol) (%)
BMI, mean Kg/m2 ± SD |
24.4
6.3 ± 1.0
45.7 ± 11.0
85.4
29.4 ± 4.8 |
29.8
6.6 ± 1.5
49.0 ± 16.5
75.7
30.5 ± 5.4 |
23.2
6.3 ± 0.9
45.5 ± 10.27
86.1
29.6 ± 4.7 |
24.1
6.2 ± 0.8
44.7 ± 8.9
88.1
28.6 ± 4.5 |
37.8
6.3 ± 1.0
45.6 ± 11.0
86.1
29.8 ± 4.9 |
25.5
6.3 ± 1.0
45.7 ± 11.0
85.2
29.4 ± 4.7 |
18.5
6.3 ± 1.0
45.8 ± 11.0
84.8
28.9 ± 4.7 |
12.7
6.3 ± 1.0
45.7 ± 11.0
84.4
28.3 ± 4.5 |
Oral monotherapy (N=101749) (%)
HbA1c, mean %
HbA1c, mean, mmol/mol ± SD
HbA1c≤ 7% (≤ 53 mmol/mol) (%)
BMI, mean Kg/m2 ± SD |
35.5
6.9 ± 1.3
52.1 ± 13.9
63.7
29.6 ± 4.9 |
36.1
7.3 ± 1.7
56.4 ± 18.2
54.0
30.9 ± 5.5 |
35.7
6.9 ± 1.2
52.1 ± 13.5
63.3
29.9 ± 4.9 |
34.9
6.7 ± 1.1
50.3 ± 11.9
68.4
28.6 ± 4.5 |
43.2
6.8 ± 1.5
51.1 ± 16.0
68.1
30.2 ± 5.1 |
37.8
6.9 ± 1.3 52.2 ± 13.8
63.1
29.7 ± 4.8 |
32.7
7.0 ± 1.2
52.8 ± 13.4
61.1
29.3 ± 4.8 |
23.5
7.0 ± 1.2
52.6 ± 13.0
60.8
28.6 ± 4.6 |
Oral Combined (N=64313) (%)
HbA1c, mean %
HbA1c, mean, mmol/mol ± SD
HbA1c≤ 7% (≤ 53 mmol/mol) (%)
BMI, mean Kg/m2 ± SD |
21.0
7.6 ± 1.5
59.3 ± 16.1
40.1
29.6 ± 5.0 |
19.3
8.1 ± 1.8
65.2 ± 19.8
30.9
31.2 ± 5.8 |
23.9
7.6 ± 1.4
59.7 ± 15.6
38.9
30.0 ± 5.1 |
21.3
7.4 ± 1.3
56.9 ± 14.4
45.6
28.4 ± 4.5 |
11.5
7.6 ± 1.7
59.3 ± 18.7
44.3
30.1 ± 5.4 |
22.0
7.6 ± 1.5
59.6 ± 16.3
40.5
29.9 ± 5.1 |
27.9
7.6 ± 1.4
59.7 ± 15.4
38.9
29.6 ± 5.0 |
29.5
7.5 ± 1.4
58.9 ± 14.9
39.5
29.0 ± 4.8 |
Oral + Insulin (N=29095) (%)
HbA1c, mean %
HbA1c, mean, mmol/mol ± SD
HbA1c≤ 7% (≤ 53 mmol/mol) (%)
BMI, mean Kg/m2 ± SD |
10.1
8.1 ± 1.6
65.4 ± 17.0
24.3
30.6 ± 5.3 |
7.9
8.7 ± 1.9
71.1 ± 20.9
20.7
31.3 ± 5.9 |
10.8
8.2 ± 1.5
65.8 ± 16.7
22.5
31.0 ± 5.4 |
10.0
7.9 ± 1.4
62.7 ± 15.8
28.4
29.5 ± 4.9 |
3.6
8.0 ± 1.9
63.7 ± 20.7
33.9
30.3 ± 5.5 |
8.2
8.1 ± 1.6
65.1 ± 17.4
25.5
30.6 ± 5.4 |
12.3
8.2 ± 1.5
65.9 ± 16.8
23.0
30.7 ± 5.3 |
20.7
8.1 ± 1.5
65.1 ± 16.0
22.5
30.5 ± 5.3 |
Insulin monotherapy (N=21710) (%)
HbA1c, mean %
HbA1c, mean, mmol/mol ± SD
HbA1c≤ 7% (≤ 53 mmol/mol) (%)
BMI, mean Kg/m2 ± SD |
7.6
7.9 ± 1.7
62.7 ± 18.5
32.9
28.6 ± 5.1 |
6.9
8.6 ± 2.2
70.9 ± 24.3
25.1
27.9 ± 5.6 |
6.4
7.9 ± 1.7
63.3 ± 18.6
31.3
29.0 ± 5.3 |
9.8
7.7 ± 1.5
60.2 ± 16.2
36.2
28.6 ± 4.9 |
3.9
7.7 ± 2.0
60.7 ± 22.2
44.9
29.2 ± 5.1 |
6.5
7.9 ± 1.7
62.4 ± 18.6
33.8
28.8 ± 5.3 |
8.6
7.9 ± 1.6
62.9 ± 17.9
31.7
28.6 ± 5.1 |
13.7
8.0 ± 1.6
63.6 ± 17.5
28.8
28.9 ± 5.0 |
