Allele/Genotype T1D Male N=144 T1D Female N=106 Controls Male N=345 Controls Female N=135 Male T1Dvs. Male Controls Female T1Dvs. Female Controls
  n(%) n(%) n(%) n(%) p value Odds Ratio 95% C.I. p value Odds Ratio 95% C.I.
Allele1858C 272 (94.4) 201
(94.8)
673
(97.5)
268
(99.25)
0.015 0.43 0.2-0.9 0.003* 0.16** 0.06-0.43
Allele1858T 16
(5.6)
11
(5.2)
17
(2.5)
2
(0.75)
0.015 2.33 1.08-4.97 0.003* 6.12** 2.3-16.26
Genotype CC 128 (88.9) 95
(89.6)
328
(96.1)
133
(98.5)
0.013 0.41 0.19-0.9 0.002* 0.15** 0.05-0.42
Genotype CT 16
(11.1)
11
(10.4)
17
(4.9)
2
(1.5)
0.013 2.4 1.1-5.2 0.002* 6.4** 2.4-17.2
*Fisher’s exact test was used to calculate p values.
**Haldane’s modification was used to calculate the Odds Ratio.
Table 2: Gender-wise distribution of allele and genotype frequencies of PTPN22 C1858T in T1D as compared to matched normal healthy controls (07.01.14).