Allele/Genotype T1D >14 years N=133 T1D ≤ 14 years N=117 ControlsN=480 Age at onset>14 yearsvs.controls Age at onset ≤ 14 yearsvs.controls
  n(%) n(%) n(%) p value Odds Ratio 95% C.I. p value Odds Ratio 95% C.I.
Allele1858C 253
(95.1)
220
(94.0)
941
(98.02)
0.008 0.39 0.18-0.88 0.0008 0.32 0.15-0.69
Allele1858T 13
(4.9)
14
(5.98)
19
(1.98)
0.008 2.54 1.1-5.5 0.0008 3.15 1.43-6.73
Genotype CC 120
(90.2)
103
(88.1)
461
(96.04)
0.0076 0.38 0.17-0.86 0.0007 0.3 0.14-0.68
Genotype CT 13
(9.8)
14
(11.9)
19
(3.96)
0.0076 2.62 1.1-5.8 0.0007 3.3 1.5-7.2
Table 3: Genotype frequencies of PTPN22 C1858T in T1D based on age at onset as compared to normal healthy controls (07.01.14).