| PTPN22 CC/CT with predisposing and protective HLA alleles |
T1DN=243 |
ControlsN=327 |
p |
Odds ratio |
95% C.I. |
| |
n |
% |
n |
% |
|
|
|
| CT- HLA-DRB1*03:01 |
24 |
9.9 |
3 |
0.91 |
6.34×10-7* |
10.34** |
4.64-23.05 |
| CC- HLA-DRB1*03:01 |
164 |
67.9 |
49 |
14.98 |
1.36 × 10-37 |
11.77 |
7.71-18.05 |
| CT- HLA-DRB1*04:01 |
2 |
0.82 |
0 |
0 |
0.18* |
6.78** |
0.78-58.22 |
| CC- HLA-DRB1*04:01 |
26 |
10.7 |
8 |
2.453 |
0.00003* |
4.78** |
2.05-12.41 |
| CT- HLA-DRB1*04:03 |
0 |
0 |
0 |
0 |
- |
- |
- |
| CC- HLA-DRB1*04:03 |
8 |
3.3 |
29 |
8.86 |
0.0075 |
0.35 |
0.14-0.8 |
| CT- HLA-DRB1*04:05 |
2 |
0.82 |
0 |
0 |
0.18* |
6.78** |
0.78-58.22 |
| CC- HLA-DRB1*04:05 |
20 |
8.23 |
1 |
0.31 |
3.17 × 10-7* |
19.96** |
6.14-64.87 |
| CT- HLA-DRB1*07:01 |
3 |
1.23 |
5 |
1.53 |
0.53* |
0.85** |
0.33-2.22 |
| CC- HLA-DRB1*07:01 |
27 |
11.11 |
98 |
29.97 |
7.39 × 10-8 |
0.29 |
0.17-0.47 |
*Fisher’s exact test was used to calculate p values
**Haldane’s modification was used to calculate the Odds Ratio. |
