Total (n=69) T1 (n=23) T2 (n=23) T3 (n=23) p
The GA/HbA1c ratio          
Range 2.02 - 3.74 2.02 - 2.54 2.55 - 2.83 2.84 - 3.74 -
Mean 2.69 ± 0.36 2.31 ± 0.15 2.68 ± 0.08 3.07 ± 0.26 <0.0001
Male (%) 46 (66.7) 16 (69.6) 15 (62.5) 15 (62.5) 0.759
Age (years) 64.8 ± 10.5 61.3 ± 9.4 60.7 ± 9.6 72.5 ± 8.1 <0.001
Diabetes duration (years) 11.0 ± 7.8 6.9 ± 4.4 12.6 ± 6.8 13.8 ± 11.3 0.017
Body mass index (kg/m2) 25.4 ± 4.7 27.1 ± 5.5 25.4 ± 3.6 23.6 ± 4.0 0.013
FPG (mg/dl) 146 ± 27 141 ± 21 145 ± 20 151 ± 35 0.186
HbA1c (%) 8.0 ± 0.9 8.0 ± 0.7 7.9 ± 0.8 8.1 ± 1.1 0.687
HbA1c (mmol/mol) 63.6 ± 9.5 63.6 ± 8.1 62.2 ± 8.6 64.9 ± 11.7 0.685
GA (%) 21.4 ± 3.6 18.3 ± 1.6 21.0 ± 2.5 24.8 ± 3.2 <0.0001
HOMA-R 2.4 (0.2-4.6) 3.6 (0.6-6.6) 2.4 (0.5-4.4) 1.7 (0.2-3.2) 0.010
HOMA-β (%) 34.2 (11.7-56.7) 42.3 (23.2-61.4) 31.0 (9.6-52.4) 23.8 (2.1-45.6) 0.002
ΔFPG (mg/dl) -13 ± 32 -13 ± 23 -4 ± 36 -23 ± 34 0.318
ΔHbA1c (%) -0.7 ± 0.8 -0.7 ± 0.6 -0.4 ± 0.6 -1.1 ± 1.1 0.383
ΔHbA1c (mmol/mol) -7.3 ± 9.2 -7.6 ± 7.0 -4.4 ± 7.1 -9.9 ± 12.2 0.403
ΔGA (%) -2.6 ± 3.0 -1.9 ± 1.4 -1.8 ± 2.4 -4.1 ± 4.0 0.010
ΔGA/HbA1c ratio -0.11 ± 0.20 -0.03 ± 0.13 -0.09 ± 0.17 -0.20 ± 0.24 0.004
ΔHOMA-R -0.1 (-1.2-1.0) -0.3 (-1.7-1.1) -0.1 (-1.4-1.2) 0 (-1.0-1.0) 0.744
ΔHOMA-β (%) 6.7 (-12.6-26.0) 7.1 (-8.0-22.2) 1.9(-9.2-13.0) 16.6 (-6.4-39.5) 0.067
Figures show the mean ± SD or median (interquartile range)
Table 1: Tertile analysis of the baseline GA/HbA1c ratios; patient characteristics and changes in laboratory values with 24 weeks of sitagliptin administration in each group