Severe hypoglycemia Symptomatic hypoglycemia
  IR (95% CI) IRR (95% CI) IR (95% CI) IRR (95% CI)
Overall 0.09
(0.08-0.11)
- 9.26
(8.81-9.73)
-
By gender        
M 0.06
(0.05-0.08)
0.46
(0.35-0.62)
7.77
(7.22-8.35)
0.70
(0.63-0.77)
F 0.14
(0.12-0.16)
1.00
(RC)
11.08
(10.35-11.86)
1.00
(RC)
By age classes        
<65 0.07
(0.05-0.09)
1.00
(RC)
8.91
(8.24-9.63)
1.00
(RC)
65-74 0.10
(0.08-0.13)
1.50
(1.07-2.11)
9.23
(8.52-10.00)
1.04
(0.93-1.16)
>=75 0.15
(0.12-0.20)
2.30
(1.60-3.31)
9.89
(8.85-11.05)
1.11
(0.97-1.27)
By diabetes duration        
<=2 0.02
(0.01-0.05)
1.00
(RC)
4.63
(3.75-5.72)
1.00
(RC)
2-5 0.08
(0.06-0.12)
3.66
(1.42-9.47)
6.63
(5.76-7.63)
1.43
(1.11-1.85)
5.1-10 0.06
(0.04-0.09)
2.66
(1.03-6.88)
7.38
(6.59-8.27)
1.60
(1.26-2.03)
>10 0.14
(0.12-0.17)
6.30
(2.58-15.38)
11.90
(11.15-12.69)
2.57
(2.06-3.21)
By cardiac/cerebrovascular disease        
NO 0.10
(0.09-0.12)
1.16
(0.79-1.70)
8.7
(8.22-9.21)
0.74
(0.65-0.83)
YES 0.09
(0.06-0.12)
1.00
(RC)
11.83
(10.67-13.13)
1.00
(RC)
By glucose lowering therapy schemes        
OHA (without
secretagogues)
0.04
(0.03-0.06)
1.00
(RC)
5.57
(4.98-6.22)
1.00
(RC)
OHA (with
secretagogues)
0.08
(0.06-0.11)
2.00
(1.24-3.21)
9.50
(8.64-10.45)
1.71
(1.48-1.98)
Insulin
(basal oral)
0.10
(0.06-0.17)
2.49
(1.31-4.73)
10.76
(9.01-12.85)
1.93
(1.57-2.38)
Insulin
(basal bolus)
0.29
(0.23-0.35)
6.91
(4.52-10.56)
18.36
(16.79-20.08)
3.30
(2.86-3.80)
Insulin
(Other schemes)
0.13
(0.08-0.19)
3.02
(1.70-5.36)
14.55
(12.64-16.75)
2.61
(2.19-3.13)
Diet 0 - 1.60
(1.10-2.34)
0.29
(0.19-0.43)
OHA: Oral Hypoglycemic Agents
RC: Reference Class
IR: Incidence Rate
95% CI: 95% Confidence Interval
IRR: Incidence Rate Ratio
Table 2: Incidence of severe and symptomatic hypoglycemia in type 2 diabetes