a. Severe hypoglycemia
| Variables |
IRR (95%CI) |
| Age |
1.02 (1.00-1.04) |
| Female gender |
2.23 (1.61-3.08) |
| Duration of diabetes |
1.02 (1.01-1.04) |
| HbA1c |
1.28 (1.14-1.44) |
| Previous severe hypoglycemia (before the past 12 months) |
3.38 (2.47-4.62) |
| Symptomatic hypoglycemic episodes in the last 4 weeks |
3.05 (2.18-4.26) |
| Therapeutic schemes |
|
| Insulin (Other schemes) |
0.91 (0.48-1.74) |
| Insulin (basal bolus) |
2.04 (1.24-3.35) |
| Insulin (basal oral) |
0.79 (0.38-1.67) |
| OHA (combination with secretagogues) |
1.07 (0.64-1.78) |
| OHA (combination without secretagogues) |
1.00 (RC) |
| Sensory-motor neuropathy |
1.73 (1.24-2.41) |
| Neoplasms |
2.08 (1.23-3.49) |
| Employment status |
|
| Retired |
0.94 (0.62-1.43) |
| Employed |
1.80 (1.08-3.01) |
| Unemployed |
1.00 (RC) |
|
b. Symptomatic hypoglycemia
| Variables |
IRR (95%CI) |
| Age |
0.98 (0.97-0.99) |
| Female gender |
1.44 (1.29-1.62) |
| Duration of diabetes |
1.02 (1.01-1.02) |
| HbA1c |
0.90 (0.86-0.95) |
| Previous severe hypoglycemia (before the past 12 months) |
1.72 (1.51-1.96) |
| GFR < 60 mL/min |
0.85 (0.74-0.99) |
| Retinopathy |
1.25 (1.10-1.42) |
| Sensory-motor neuropathy |
1.20 (1.04-1.39) |
| Therapeutic schemes |
|
| Insulin (Other schemes) |
2.15 (1.75-2.65) |
| Insulin (basal bolus) |
2.59 (2.18-3.09) |
| Insulin (basal oral) |
1.76 (1.39-2.23) |
| OHA (combination with secretagogues) |
1.63 (1.39-1.91) |
| OHA (combination without secretagogues) |
1.00 (RC) |
| Beta-blockers treatment |
0.84 (0.73-0.96) |
| Number of drugs other than antidiabetic ones |
1.02 (1.00-1.05) |
| Living status |
|
| Other |
1.54 (1.17-2.02) |
| Other family members |
0.70 (0.52-0.95) |
| Alone |
1.32 (1.15-1.53) |
| Spouse/sons |
1.00 (RC) |
| Taking care of other people |
1.45 (1.29-1.62) |
| Employment status |
|
| Retired |
1.39 (1.19-1.63) |
| Employed |
1.08 (0.89-1.30) |
| Unemployed |
1.00 (RC) |
RC: Reference Class |
Table 3: Factors associated with risk of hypoglycemia. Results of the Poisson
multivariate analysis
Table shows only statistically significant rate ratios (95% confidence intervals). |
