a. Severe hypoglycemia
Variables IRR (95%CI)
Age 1.02 (1.00-1.04)
Female gender 2.23 (1.61-3.08)
Duration of diabetes 1.02 (1.01-1.04)
HbA1c 1.28 (1.14-1.44)
Previous severe hypoglycemia (before the past 12 months) 3.38 (2.47-4.62)
Symptomatic hypoglycemic episodes in the last 4 weeks 3.05 (2.18-4.26)
Therapeutic schemes  
Insulin (Other schemes) 0.91 (0.48-1.74)
Insulin (basal bolus) 2.04 (1.24-3.35)
Insulin (basal oral) 0.79 (0.38-1.67)
OHA (combination with secretagogues) 1.07 (0.64-1.78)
OHA (combination without secretagogues) 1.00 (RC)
Sensory-motor neuropathy 1.73 (1.24-2.41)
Neoplasms 2.08 (1.23-3.49)
Employment status  
Retired 0.94 (0.62-1.43)
Employed 1.80 (1.08-3.01)
Unemployed 1.00 (RC)
b. Symptomatic hypoglycemia
Variables IRR (95%CI)
Age 0.98 (0.97-0.99)
Female gender 1.44 (1.29-1.62)
Duration of diabetes 1.02 (1.01-1.02)
HbA1c 0.90 (0.86-0.95)
Previous severe hypoglycemia (before the past 12 months) 1.72 (1.51-1.96)
GFR < 60 mL/min 0.85 (0.74-0.99)
Retinopathy 1.25 (1.10-1.42)
Sensory-motor neuropathy 1.20 (1.04-1.39)
Therapeutic schemes  
Insulin (Other schemes) 2.15 (1.75-2.65)
Insulin (basal bolus) 2.59 (2.18-3.09)
Insulin (basal oral) 1.76 (1.39-2.23)
OHA (combination with secretagogues) 1.63 (1.39-1.91)
OHA (combination without secretagogues) 1.00 (RC)
Beta-blockers treatment 0.84 (0.73-0.96)
Number of drugs other than antidiabetic ones 1.02 (1.00-1.05)
Living status  
Other 1.54 (1.17-2.02)
Other family members 0.70 (0.52-0.95)
Alone 1.32 (1.15-1.53)
Spouse/sons 1.00 (RC)
Taking care of other people 1.45 (1.29-1.62)
Employment status  
Retired 1.39 (1.19-1.63)
Employed 1.08 (0.89-1.30)
Unemployed 1.00 (RC)
RC: Reference Class
Table 3: Factors associated with risk of hypoglycemia. Results of the Poisson multivariate analysis
Table shows only statistically significant rate ratios (95% confidence intervals).