Parameter Input Reference Dose 1000 [2] Dosage form immediate release [2] Molecular weight 129.17 ADMET Predictor 6 LogD(7.4) -3.37 [28] Solubility 134.87 mg/mL @ pH=12.9 ADMET Predictor 6 Permeability Papp, total= 0.05x 10-5cm/s Paracellular = .4467 x 10-4cm/s Transcellular = 0.0001 x 10-4cm/s ADMET Predictor 6Proctor, 2010) pKa 10.17, 7.14 ADMET Predictor 6

Table 1: Inputs parameters used in control and post gastric bypass in the compound window of GastroPlus™.