Transporter Location Transporter kinetics Reference PMAT Intestine Km= 1.32 mM [13] OCT1 Liver Km=1.47mM Vmax =396pmol/min/mg protein [17] OCT2 Kidney Km=0.99mM, Vmax =1444pmol/min/mg protein [17] MATE1 Liver and Kidney Km= 0.78mM, Vmax = 4.46nmol/min/mg protein [16] MATE-K2 Kidney Km= 1.98mM, Vmax = 1.69nmol/min/mg protein [16]

Table 2: Inputs parameters used in control and post gastric bypass in the transporter window of GastroPlusTM.