Ki Value (nM)

Rat SGLT1 Rat SGLT2
Sergliflozinetabonate 3350 ± 110 651 ± 149
Sergliflozin 704 ± 254 17.1 ± 2.6
Phlorizin 275 ± 153 41.8 ± 11.4
Data are presented as means ± S.E.M. from 3 experiments. An AMG uptake experiment was performed with COS-7 cells transiently transfected with rat SGLT1 or SGLT2, and the Ki values for each SGLT were calculated [20].
Table 2: Ki values of sergliflozinetabonate, sergliflozin, and phlorizin for rat SGLTs.