Time 8 weeks of HFD 22 weeks of HFD 22 weeks of HFD Clamp
strain WT CPT1b+/- WT CPT1b+/- WT CPT1b+/-
Glucose (mg/dl) 82.7 ± 3.3 73.1 ± 4* 148 ± 6.3‡‡ 109 ± 11‡‡* 162 ± 28 158 ± 25
NEFA (mEq/L) 1.3 ± 0.2 1.0 ± 0.2 1.1 ± 0.1 1.3 ± 0.2 0.9 ± 0.14 0.5 ± 0.06*
Insulin (μIU/ml) 6.3 ± 0.4 6.3 ± 0.4 10.7 ± 0.9‡‡ 8.3 ± 0.6‡* 37.5 ± 7.5 45 ± 4.9
Leptin (μg/L) 5.0 ± 2 27.1 ± 21 35.4 ± 11‡ 19.4 ± 4.0 ND ND
Mice were fasted for overnight. n=4-7, *p<0.05, **p<0.01 between WT and CPT1b+/- mice within the same time point, ‡p<0.05, ‡‡p<0.01 between 8 and 22 weeks within the
same group.
Table 1: Plasma lipid and hormone profile after 8 weeks, 22 weeks of HFD feeding, and insulin clamp (n=7-8).