| Time |
8 weeks of HFD |
22 weeks of HFD |
22 weeks of HFD Clamp |
| strain |
WT |
CPT1b+/- |
WT |
CPT1b+/- |
WT |
CPT1b+/- |
| Glucose (mg/dl) |
82.7 ± 3.3 |
73.1 ± 4* |
148 ± 6.3‡‡ |
109 ± 11‡‡* |
162 ± 28 |
158 ± 25 |
| NEFA (mEq/L) |
1.3 ± 0.2 |
1.0 ± 0.2 |
1.1 ± 0.1 |
1.3 ± 0.2 |
0.9 ± 0.14 |
0.5 ± 0.06* |
| Insulin (μIU/ml) |
6.3 ± 0.4 |
6.3 ± 0.4 |
10.7 ± 0.9‡‡ |
8.3 ± 0.6‡* |
37.5 ± 7.5 |
45 ± 4.9 |
| Leptin (μg/L) |
5.0 ± 2 |
27.1 ± 21 |
35.4 ± 11‡ |
19.4 ± 4.0 |
ND |
ND |
Mice were fasted for overnight. n=4-7, *p<0.05, **p<0.01 between WT and CPT1b+/- mice within the same time point, ‡p<0.05, ‡‡p<0.01 between 8 and 22 weeks within the
same group. |
