Variables FGF-23 ET-1 sICAM IL6 PAI-1 TNFα sVCAM IL-1β CD146 CRP FGF-23 1.00 0.13 -0.17 0.36* 0.21* 0.01 -0.12 -0.12 0.29* 0.14 Calcium (mg/dL) 0.11 -0.26* 0.08 -0.47* -0.11 0.04 -0.06 -0.12 -0.10 -0.27* Phosphate (mg/dL) 0.54* 0.49* -0.11 0.45* 0.11 0.07 0.20* 0.24* 0.22* 0.19 Ca× PO4product 0.63* 0.41* -0.09 0.29* 0.07 0.09 0.19 0.20 0.19 0.09 Triglyceride (mg/dL) -0.23 -0.16 0.48* 0.05 0.34* 0.11 -0.33* 0.31* 0.19 -0.001 LDL (mg/dL) -0.28* 0.08 0.19 -0.47* -0.14 -0.15 0.11 0.18 -0.02 -0.17 HDL (mg/dL) -0.004 0.26* -0.42* 0.01 -0.16 -0.18 0.53* -0.05 -0.34* 0.10 Total Cholesterol -0.35 0.19 0.30 -0.36 0.02 -0.14 0.14 0.35 0.01 -0.06 Intact PTH (pg/mL) -0.02 0.12 -0.05 0.02 0.01 -0.08 0.02 -0.04 -0.29* 0.03

Table 2: Spearman correlation between markers of mineral metabolism and cardiovascular risks factors; FGF-23: Fibroblast Growth factor–23; ET-1: Endothelin-1; sICAM: soluble Intercellular Adhesion Molecule; IL6: Interleukin 6; PAI-1: Plasminogen Activator Iinhibitor-1; TNFα: Tumor Necrosis Factor-alpha; sVCAM: soluble Vascular Adhesion Molecule-1; IL-1β: Interleukin 1β; CD 146: Cluster of Differentiation 146; CRP:C-Reactive Protein; Ca× PO4product: Calcium Phosphorus product; LDL: Low-Density Lipoprotein; HDL: High-Density Lipoprotein. * p<0.05 correlations are statistically significant. Serum concentrations of FGF-23, sICAM, PAI-1, sVCAM, and CD146 were measured in ng/mL; Serum concentrations of ET-1, IL-6, TNFα, IL-1β, and CRP were measured in pg/mL.