Biguanides duration and dosean= 10,727
  N Odds Ratio P (95% CI)
Duration (years)      
0 2,886 2.560 0.001 (1.843-3.556)
0-1 850 4.544 0.001 (2.901-7.120)
1-2 1,004 5.890 0.001 (3.932-8.824)
2-3 809 3.161 0.001 (1.996-5.005)
3-4.1* 5,007 1 ref  
 
Dose (sum daily doses of 2 g metformin )
0 2,896 3.080 0.001 (1.996-4.753)
1-200 1,530 3.595 0.001 (2.231-5.791)
200-500 1,552 3.736 0.001 (2.340-5.964)
500-1000* 1,916 2.150 0.002 (1.323-3.495)
1000-3450* 2,833 1 ref  
Table 6: Effects of biguanide duration and dose in DM patients Results are unadjusted for biochemistry. Odds ratio shows the risk of developing AMI if the case has received certain duration and certain total daily dose of biguanides.