Biguanides duration and dose
a
n= 10,727
N
Odds Ratio
P (95% CI)
Duration (years)
0
2,886
2.560
0.001 (1.843-3.556)
0-1
850
4.544
0.001 (2.901-7.120)
1-2
1,004
5.890
0.001 (3.932-8.824)
2-3
809
3.161
0.001 (1.996-5.005)
3-4.1*
5,007
1 ref
Dose (sum daily doses of 2 g metformin )
0
2,896
3.080
0.001 (1.996-4.753)
1-200
1,530
3.595
0.001 (2.231-5.791)
200-500
1,552
3.736
0.001 (2.340-5.964)
500-1000*
1,916
2.150
0.002 (1.323-3.495)
1000-3450*
2,833
1 ref
Table 6:
Effects of biguanide duration and dose in DM patients Results are unadjusted for biochemistry. Odds ratio shows the risk of developing AMI if the case has received certain duration and certain total daily dose of biguanides.
