| |
Normotensive |
PE |
P |
| Maternal characteristics at enrolment |
| Maternal Age (years) |
32.9 (32.5-33.3) |
31.44 (29.58-33.29) |
0.12 |
| Nulliparous n(%) |
204 (31.3) [652] |
20 (43.5) |
0.09 |
| Metformin treatment |
330 (50.2) |
20 (43.5) |
0.78 |
| Caucasian n(%) |
319 (48.6) |
18 (39.1) |
0.02
|
| Indian n(%) |
89 (13.5) |
4 (8.7) |
| Polynesian n(%) |
134 (20.4) |
19 (41.3) |
| Asian n(%) |
86 (13.1) |
4 (8.7) |
| Other n(%) |
29 (4.4) |
1 (2.2) |
| Tertiary education n(%) |
292 (44.9) |
17 (37.0) |
0.30 |
| Aspirin use in pregnancy |
40 (6.1) |
3 (6.5) |
0.91 |
| Personal history of chronic hypertension |
48 (7.3) |
9 (19.6) |
0.003 |
| Previous preeclampsia * |
43 (9.2) [448] |
8(30.8) [26] |
<0.001 |
| Family history of preeclampsia |
58 (8.8) |
8 (17.4) |
0.05 |
| Personal or family history of preeclampsia |
93 (14.2) |
14 (30.4) |
0.003 |
| Smoking in pregnancy n(%) |
106 (16.1) |
9 (19.6) |
0.54 |
| Gestational age at enrolment (weeks) |
30.1 (29.8-30.3) |
30.40 (29.62-31.18) |
0.96 |
| BMI in early pregnancy (kg/m2) |
31.89 (31.22-32.56) [535] |
33.49 (30.74-36.23) [29] |
0.22 |
| Change in maternal weight from early pregnancy to randomization (kg) |
6.50 (6.05-6.95) [533] |
9.44 (6.53-12.37) [29] |
0.10 |
| Systolic BP at enrolment (mmHg) |
112.0 (111.0-113.0) [641] |
124.9 (121.0-128.7) |
<0.001 |
| Diastolic BP at enrolment (mmHg) |
67.6 (66.9-68.3) |
77.0 (74.4-79.7) |
<0.001 |
| Fasting glucose (mmol/L) |
5.20 (5.12-5.28) [558] |
5.76 (5.21-6.31) [35] |
0.09 |
| HbA1c (%) |
5.73 (5.67-5.78) [598] |
6.14 (5.84-6.45) [39] |
0.003 |
| Fasting triglycerides (mmol/L) |
2.55 (2.47-2.62) [550] |
2.93 (2.57-3.29) [37] |
0.03 |
| Fasting cholesterol (mmol/L) |
6.07 (5.91-6.24) [342] |
5.82 (5.22-6.42) [22] |
0.37 |
| Fasting HDL-cholesterol (mmol/L) |
1.72 (1.67-1.76) [350] |
1.53 (1.38-1.68) [22] |
0.08 |
| Fasting LDL-cholesterol (mmol/L) |
3.21 (3.06-3.36) [342] |
2.87 (2.38-3.36) [22] |
0.25 |
| Infant Characteristics |
|
|
|
| Gestational age at delivery (days) |
269.3 (268.6-270.0) |
261.6 (258.4-264.8) |
<0.001 |
| Born less than 37 weeks n(%) |
55 (8.4) |
15 (32.6) |
<0.001 |
| Female n(%) |
322 (49.0) |
20 (43.5) |
0.47 |
| Adjusted birth weight centile (%)*** |
54.10 (51.76-56.44) |
52.44 (42.14-62.74) |
0.82 |
| <10th centile n(%) |
68 (10.4) |
8 (17.4) |
0.14 |
| APGAR 1 min ** |
9 |
9 |
0.44 |
| APGAR 5 min ** |
9 |
10 |
0.37 |
| Cord glucose (mmol/L) |
4.73 (4.59-4.88) [417] |
4.23 (3.69-4.77) [15] |
0.23 |
| Cord triglycerides (mmol/L) |
0.41 (0.39-0.43) [419] |
0.52 (0.36-0.68) [15] |
0.11 |
