Univariate P Model I P Model II P Model III P
OR (95%CI) OR (95%CI) OR (95%CI) OR (95%CI)
Maternal Age (years) 0.95 (0.90-1.01) 0.07 0.96 (0.91-1.02) 0.15 0.97 (0.91-1.03) 0.29 0.97 (0.93-1.07) 0.92
Personal or family history PE 2.65 (1.36-5.16) 0.004 2.80 (1.43-5.51) 0.003 2.66 (1.28-5.57) 0.01 1.77 (0.73-4.33) 0.21
Polynesian Ethnicity 2.75 (1.48-5.09) 0.001 2.87 (1.54-5.35) 0.001 2.03 (0.98-4.22) 0.06 2.93 (1.26-6.85) 0.01
Nulliparity 1.69 (0.92-3.10) 0.09 2.66 (1.37-5.20) 0.004 2.61 (1.25-5.42) 0.01 2.35 (1.04-5.30) 0.04
Smoking 1.26 (0.59-2.70) 0.54 1.19 (0.55-2.58) 0.66 1.35 (0.58-3.11) 0.49 1.27 (0.49-3.26) 0.62
Metformin Therapy 0.76 (0.42-1.39) 0.38 0.78 (0.42-1.44) 0.42 0.93 (0.48-1.81) 0.83 0.87 (0.41-1.86) 0.72
Maternal BMI in early pregnancy (kg/m2) 1.03 (0.98-1.07) 0.29 1.00 (0.95-1.06) 0.9 1.01 (0.96-1.07) 0.67 - -
Weight gain from early pregnancy to enrolment (kg) 1.09 (1.03-1.17) 0.01 1.08 (1.02-1.15) 0.02 1.08 (1.00-1.15) 0.04 - -
HbA1c (%) 1.96 (1.35-2.89) <0.001 1.48 (1.08-2.04) 0.02 - - 1.74 (1.05-2.87) 0.03
Fasting glucose (mmol/L) 1.48 (1.15-1.91) 0.002 1.71 (1.13-2.58) 0.01 - - 1.60 (1.13-2.27) 0.01
Fasting triglycerides (mmol/L) 1.45 (1.07-1.97) 0.02 1.31 (1.00-1.72) 0.05 1.40 (1.01-1.95) 0.05 1.66 (1.14-2.42) 0.01
Fasting cholesterol (mmol/L)* 0.89 (0.66-1.20) 0.44 0.97 (0.70-1.33) 0.83 0.95 (0.69-1.30) 0.73 0.94 (068-1.31) 0.72
Fasting HDL-cholesterol (mmol/L) * 0.29 (0.09-0.94) 0.04 0.26 (0.08-0.86) 0.03 0.30 (0.09-0.94) 0.04 0.29 (0.08-1.09) 0.07
Fasting LDL-cholesterol (mmol/L) * 0.82 (0.57-1.17) 0.27 0.89 (0.62-1.28) 0.54 0.89 (0.61-1.30) 0.55 0.83 (0.55 - 1.24) 0.36
Table 2: Logistic regression for the outcome of preeclampsia diagnosis using variables at enrolment in study (i.e. the point women were started on pharmacotherapy for GDM), showing Univariate then adjusted models. These regressions include PE and normotensive women, but did not include those women with gestational hypertension in the cohort. For each association, univariable relations are presented in the first column. Model I is each variable adjusted for Polynesian ethnicity (1=yes) and personal or family history of preeclampsia (1=yes). Model II is each variable adjusted for the variables in Model I as well as HbA1c at enrolment. Model III is each variable adjusted for the variables in Model I as well as BMI in early pregnancy. *Due to the lower numbers in these variables, Model I is each variable adjusted for Polynesian ethnicity (1=yes). Model II is adjusted for HbA1c at enrolment. Model III is adjusted for BMI in early pregnancy.