| Variable |
Total cohort; n=459 |
DM patients; n=220 |
Non-DM patients; n=239 |
P value |
| Age (years) |
49 ± 12 |
52 ± 11 |
46 ± 12 |
0.00 |
| Proportion Female |
278 (60.7%) |
152 (69.1%) |
126 (52.9%) |
0.00 |
| BMI (kg/m2) |
35.9 ± 8.5 |
37.0 ± 7.9 |
35.0 ± 9.0 |
0.01 |
| Presence of HTN |
259 (56.4%) |
156 (70.9%) |
103 (43.1%) |
0.00 |
| Presence of DM |
220 (47.9%) |
NA |
NA |
- |
| Use of Insulin |
52 (11.3%) |
52 (23.7%) |
NA |
- |
| Use of Metformin |
94 (20.5%) |
94 (42.7%) |
NA |
- |
| Use of Sulfonylurea |
67 (14.6%) |
67 (30.6%) |
NA |
- |
| Use of Statin |
123 (26.9%) |
88 (40.2%) |
35 (14.6%) |
0.00 |
| Use of ACE-I/ARB |
175 (38.1%) |
107 (48.6%) |
68 (28.5%) |
0.00 |
| Serum Bilirubin (mg/dL) |
0.68 ± 0.40 |
0.69 ± 0.43 |
0.67 ± 0.38 |
0.61 |
| AST (U/L) |
56.8 ± 65.6 |
54.3 ± 35.9 |
59.1 ± 84.1 |
0.44 |
| ALT (U/L) |
72.4 ± 56.4 |
65.3 ± 50.1 |
78.9 ± 60.9 |
0.01 |
| Albumin (g/dL) |
4.2 ± 0.5 |
4.1 ± 0.5 |
4.3 ± 0.4 |
0.01 |
| INR |
1.03 ± 0.17 |
1.04 ± 0.18 |
1.02 ± 0.16 |
0.36 |
| Platelet count (k/uL) |
238.0 ± 77.3 |
231.6 ± 79.1 |
243.7 ± 75.3 |
0.10 |
| Creatinine (mg/dL) |
0.89 ± 0.38 |
0.85 ± 0.51 |
0.92 ± 0.19 |
0.08 |
| Total cholesterol (mg/dL) |
198.5 ± 51.7 |
193.9 ± 54.9 |
202.5 ± 48.5 |
0.09 |
| TG (mg/dL) |
207.1 ± 186.5 |
232.7 ± 231.0 |
184.5 ± 132.4 |
0.01 |
| HDL (mg/dL) |
42.6 ± 10.4 |
41.5 ± 10.3 |
43.6 ± 10.0 |
0.05 |
| LDL (mg/dL) |
123.6 ± 43.2 |
116.4 ± 45.2 |
130.0 ± 40.3 |
0.00 |
| HbA1C % |
6.5 ± 1.4 |
7.40 ± 1.51 |
5.60 ± 0.57 |
0.00 |
| Ferritin (ng/mL) |
231.2 ± 233.6 |
206.4 ± 233.9 |
253.9 ± 231.6 |
0.05 |
| Grade of steatosis |
1.9 ± 0.8 |
1.9 ± 0.8 |
1.9 ± 0.8 |
0.96 |
| Grade of lobular inflammation |
1.4 ± 0.7 |
1.5 ± 0.6 |
1.4 ± 0.7 |
0.02 |
| Grade of ballooning |
1.1 ± 0.7 |
1.2 ± 0.7 |
0.9 ± 0.7 |
0.00 |
| NAS |
4.5 ± 1.6 |
4.7 ± 1.6 |
4.3 ± 1.6 |
0.01 |
| Stage of fibrosis |
1.6 ± 1.3 |
2.0 ± 1.3 |
1.1 ± 1.2 |
0.00 |
| Presence of advanced fibrosis |
132 (28.8%) |
91 (41.6%) |
41 (17.2%) |
0.00 |
Data expressed as mean ± SD or number and percentages (%).
SD: Standard Deviation; BMI: Body Mass Index; HTN: Hypertension; DM: Diabetes;
ACE-I: Angiotensin Converting Enzyme Inhibitor; ARB: Angiotensin II Receptor
Blocker; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; INR:
International Normalised Ratio; TG: Triglyceride; HDL: High Density Lipoprotein
Cholesterol; LDL: Low Density Lipoprotein Cholesterol; NAS: NAFLD activity
score; NA: Not applicable |
