| Trial[follow-up] |
N |
Intervention |
Outcome measure |
Relative RR |
Absolute RR |
NNT |
p-value |
| Diabetic retinopathy |
| ACCORD-EYE [13][4 years] |
2,856 |
Intensive vs. standard glycemic control |
Progression ≥3 steps of ETDRS, laser photocoagulation or vitrectomy |
37% |
3.1% |
32 |
0.003 |
| |
1,263 |
Intensive vs. standard BP control |
23% |
-1.6% |
- 62 |
0.29 |
| ADVANCE [15,19] [5 years] |
11,140 |
Intensive glycemic control |
New or worsening retinopathy |
5% |
0.3% |
333 |
NR |
| [4.3 years] |
|
Intensive vs. standard BP control |
|
1% |
-0.1% |
-100 |
NR |
| VADT (14)[5.6 years] |
1,791 |
Intensive vs. standard glycemic control |
Progression ≥2 steps of ETDRS |
23% |
5.1% |
19 |
0.07 |
| UKPDS* [11,12][Up to 12 years] |
3,867 |
Intensive vs. standard glycemic control |
2-step progression of ETDRS Retinal photocoagulation |
21%29% |
10.1%2.7% |
1037 |
0.0150.003 |
| |
1,148 |
Intensive vs. standard BP control |
2-step progression of ETDRS Retinal photocoagulation |
34%35% |
17.3%4.0% |
625 |
0.00380.023 |
| Renal outcomes |
| ACCORD [16][5 years] |
10,251 |
Intensive vs. standard glycemic control |
New-onset microalbuminuriaNew-onset macroalbuminuria |
15%29% |
3.1%1.7% |
3258 |
0.00120.0003 |
| ADVANCE [15,19][5 years] |
11,140 |
Intensive vs. standard glycemic control |
New or worsening nephropathyNew onset microalbuminuria |
21%9% |
1.1%2.0% |
9150 |
0.0060.02 |
| [4.3 years] |
|
Combination BP vs. standard control |
New or worsening nephropathyNew onset microalbuminuria |
18%21% |
0.6%4% |
16725 |
0.055<0.0001 |
| VADT [14][5.6 years] |
1,791 |
Intensive vs. standard glycemic control |
Any increase in albuminuria Progression to macroalbuminuria |
34%43% |
4.7%2.2% |
2145 |
0.030.04 |
| UKPDS* [11,12][Up to 15 years] |
3,867 |
Intensive vs. standard glycemic control |
Microalbuminuria |
30% at 15 yr |
11.9% at 15 yr |
8 |
0.033 |
| [Up to 9 years] |
1,148 |
Intensive vs. standard BP control |
Urinary albumin ≥50 mg/L |
29% at 6 yr13% at 9 yr |
8.2% at 6 yr4.3% at 9 yr |
1223 |
0.00850.33 |
