| Animal models |
Characterization of infections in diabetic mice |
Infection route |
Cellular or molecular observation in diabetic mice with TB |
Reference |
| STZ (200mg/kg)-induced diabetes in ICR mice (T1D) with Mtb (Schacht strain) infection |
Reduced survival time and decreased survival incidence after Mtbinfection |
Intravenous injection |
Depression of T cell function and macrophage phagocytosis |
[14] |
| GK/ Jcl rat (T2D) with Mtb (Kurono strain) infection |
Larger granulomas, higher colony-forming units count in lung and spleen tissues after infection for 3 weeks |
Airborne route infection |
Less TNF-a, IL-12 secretion and NO production in alveolar macrophages stimulated with Mtb. |
[15] |
| STZ (150mg/kg)-induced diabetes in ICR mice (T1D) with Mtb(H37Rv strain) infection |
Increased bacterial loads in lung, liver and spleen |
Intravenous
injection |
Less expression level of Th1-related cytokines and iNOS in lung, liver and spleen |
[16] |
STZ(150mg/kg)-induced diabetes in C57BL/6 mice (T1D) with Mtb (Erdman strain) infection
Akita mice (T1D) with Mtb(Erdman strain) infection |
Higher bacterial lung burden and increased extent of lung inflammation |
Airborne route infection |
Increase in IFN-gand inflammatory cytokines in pooled lung lysates. Reduced antigen-specific and -nonspecific IFN-gproduction in lung T cells. |
[17, 18] |
| Diet-induced hyperglycemia in non-diabetic guinea pig (non-DM) with Mtb(H37Rv strain) infection |
Higher lung and extrapulmonaryMtblesion burden in sucrose-
induced hyperglycemia guinea pig |
Airborne route infection |
Hyperglycemia-mediated AGE accumulation in lung |
[19] |
