Table 1

A. In genotyping study

	NGT	T2D	*NGT vs.* T2D P-value (FHD-/ FHD +)**
N (FHD-/+)	511 (402/109)	177 (41/136)	*NGT vs.* T2D P-value (FHD-/ FHD +)**
Age (years)	57 (57-58)/57 (56-58)	60 (58-61)/ 58 (57-59)	0.003/ <0.001
BMI (kg/m²)	25.8 (25.5-26.0)/26.0 (25.4-26.7)	29.4 (27.9-30.8)/30.1 (29.3-30.9)	<0.001/ <0.001
f-Glucose (mmol/l)	5.0 (4.9-5.0)/5.1 (5.0-5.2)	7.0 (6.5-7.5)/8.2 (7.7-8.6)	<0.001/ <0.001
2h-Glucose (mmol/l)	4.9 (4.8-5.0)/5.2 (5.0-5.5)	13.4 (12.5-14.4)/14.0 (13.1-15.0)	<0.001/ <0.001
f-Insulin (pmol/l)*	92.7 (89.1-96.4)/99.0 (91.2-107.4)	150.3 (122.9-183.6)/ 167.3 (154.5-181.1)	<0.001/ <0.001
2h-Insulin (pmol/l)*	291.2 (276.7-306.5) /325.9 (292.5-363.3)	496.8 (405.3-609.1)/ 535.8 (468.8-612.5)	<0.001/ <0.001
HOMA-IR	3.20 (3.06-3.34)/3.51 (2.16-3.85)	8.28 (6.55-10.01)/9.67 (8.73-10.60)	<0.001/ <0.001
SBP (mmHg)	133 (131-134)/135 (131-139)	145 (140-151)/145 (142-148)	<0.001/ <0.001
DBP (mmHg)	82 (81-82)/82 (81-85)	88 (85-92)/87 (86-89)	<0.001/ <0.001

B. In DNA methylation analysis

	NGT	T2D	*NGT vs.* T2D P -value (FHD-/ FHD +)**
N (FHD-/+)	242 (178/64)	164 (38/126)	*NGT vs.* T2D P -value (FHD-/ FHD +)**
Age (years)	58 (57-58)/57 (56-59)	60 (59-61)/ 58 (57-59)	0.010/ 0.739
BMI (kg/m²)	26.3 (26.0-26.6)/25.6 (25.1-26.1)	29.0 (27.6-30.3)/ 30.1 (29.3-30.9)	<0.001/ <0.001
f-Glucose (mmol/l)	5.0 (4.9-5.1)/5.0 (4.9-5.1)	6.9 (6.4-7.4)/ 8.2 (7.7-8.7)	<0.001/ <0.001
2h-Glucose (mmol/l)	4.9 (4.7-5.1)/5.2 (4.9-5.4)	13.4 (12.4-14.4)/ 14.1 (13.1-15.1)	<0.001/ <0.001
f-Insulin (pmol/l)*	96.6 (91.0-102.5)/97.0 (87.8-107.2)	149.0 (120.1-184.7)/ 167.8 (154.3-182.5)	<0.001/ <0.001
2h-Insulin (pmol/l)*	307.0 (283.1-332.9)/ 332.9 (290.0-382.1)	512.5 (413.9-634.7)/ 537.9 (467.0-619.6)	<0.001/ <0.001
HOMA-IR	3.35 (3.13-3.57)/3.35 (2.96-3.73)	8.19 (6.34-10.05)/ 9.80 (8.81-10.79)	<0.001/ <0.001
SBP (mmHg)	136 (134-138)/130 (130-139)	145 (140-151)/145 (142-148)	<0.001/ <0.001
DBP (mmHg)	82 (82-84)/84 (81-86)	88 (84-92)/ 87 (86-89)	0.004/ 0.017

Data were expressed as means (95% CI) for normally distributed variables and as geometric means (95% CI) for *non-normally distributed variables; FHD: Family history of diabetes; NGT: Normal glucose tolerance; T2D: Type 2 diabetes; BMI: Body mass index; IR: Insulin resistance index; SBP and DBP: Systolic and Diastolic blood pressures.

Table 1: Clinical parameters of Swedish men.