T2DM patients       (n = 3274) Nondiabetic subjects (n = 1124) P* value A-C 0.937 0.952 0.023 A-T 0.009 0.006   G-C 0.011 0.011   G-T 0.052 0.031

n = number of chromosomes. The first letter of the haplotype refers to Asp299Gly(A/G) and the second to Thr399Ile (C/T). *P values for the comparisons ofhaplotypic frequencies between T2DM patients and nondiabetic subjects werecalculated using permutation tests (10,000 replications).

Table 2: TLR4 gene haplotypes in T2DM patients and nondiabetic subjects.