Inheritance model n studies n cases n controls I2(%) Pooled OR (95% CI) Sensibility analysis*
            I2(%) Pooled OR (95% CI)
Asp299Gly              
Allelecontrast
European descendent
Brazilians
Mexicans
7
4
2
1
3904
1700
1883
321
4348
3043
770
535
81.5
87.5
4.4
-
0.68 (0.46 – 1.00)
0.64 (0.34 – 1.22)
0.59 (0.45 – 0.79)
1.35 (0.78 – 2.32)
77.2 0.60 (0.41 – 0.88)
Dominant
European descendent
Brazilians
Mexicans
5
2
2
1
3285
1081
1883
321
2374
1069
770
535
64.6
0.0
0.0
64.6
0.89 (0.6 – 1.30)
1.16 (0.80 – 1.68)
0.62 (0.47 – 0.82)
1.36 (0.78 – 2.37)
27.9 0.68 (0.48 – 0.96)
Thr399Ile              
Allelecontrast
European descendent
Brazilians
Mexicans
6
3
2
1
3581
1367
1895
319
2384
1062
784
538
81.5
90.5
54.3
-
0.65 (0.39 – 1.07)
0.65 (0.24 – 1.79)
0.46 (0.19 – 1.12)
1.13 (0.64 – 2.00)
79.3 0.56 (0.32 – 0.97)
Dominant
European descendent
Brazilians
Mexicans
5
2
2
1
3295
1081
1895
319
1971
649
784
538
59.7
0.0
50.0
-
0.85 (0.58 – 1.26)
1.14 (0.78 – 1.65)
0.60 (0.45 – 0.81)
1.13 (0.63 – 2.03)
49.6 0.66 (0.40 – 1.10)
Where significant heterogeneity was detected (I2> 50%), the DerSimonian and Laird Random Effect Model (REM) was used to calculate OR (95% CI) for each individual study and for the pooled effect; where heterogeneity was not significant, the Fixed Effect Model (FEM) was used for this calculation. * Sensibility analysis excluding the Buraczynska et al. [19] or to eliminate the heterogeneity.
Table 4: Meta-analysis pooled measures for associations between the TLR4 Asp299Gly and Thr399Ile polymorphisms and the susceptibility to T2DM.