Parameter NP+ND GD+FSD
HOMA-IR [[(Fasting Insulin, µIU/ml) × (Fasting Glucose, mmol/L)]/22.5] 4.27 ± 0.15 25.50 ± 0.51*
QUICKI [1/ [Log (Fasting Insulin, µIU/ml) + Log (Fasting Glucose, mg/dL)]] 0.31 ± 0.001 0.25 ± 0.001*
HbA1c (%) 4.87 ± 0.12 6.86 ± 0.08*
Fructosamine (mmol/L) 45.39 ± 3.05 185.70 ± 5.25*
Liver glycogen content (mg/g tissue) 12.69 ± 0.57 3.55 ± 0.19*
Triglycerides (mg/dL) 58.72 ± 1.44 189.64 ± 1.34*
Total Cholesterol (mg/dL) 81.12 ± 1.45 185.13 ± 2.51*
HDL-Ch.(mg/dL) 58.06 ± 1.54 52.52 ± 1.18#
LDL-Ch. (mg/dL) [Total-Ch – T.G/5 – HDL-Ch.] 11.95 ± 0.51 94.59 ± 2.74*
vLDL-Ch. (mg/dL) [T.G./5] 11.74 ± 0.29 37.93 ± 0.26*
CVR1[Total-Ch./HDL-Ch.] 1.37 ± 0.05 3.53 ± 0.09*
CVR2 [LDL-Ch./HDL-Ch.] 0.20 ± 0.01 1.80 ± 0.08*
AAI [HDL-Ch.×100 / Total Ch. – HDL-Ch.] 290.85 ± 20.96 40.19± 1.47*
Leptin (pg/ml) 574.65 ± 46.38 1265.40 ± 42.15*
TNF-α (pg/ml) 210.77 ± 4.42 374.40 ± 7.19*
Adiponectin (pg/ml) 946.68 ± 4.54 693.95 ± 16.73*
Data shown as mean ± SEM of six dams #P<0.05, *P<0.001 versus NP+ND group NP+ND: Normal pregnant dams received normal diet, GD+FSD: Gestational diabetic dams received fatty sucrosed diet/minimal dose of STZ (25 mg/kg b.wt.).
Table 3: Maternal glucose-insulin homeostasis, lipid profile and adipocytokines of NP+ND and GD+FSD after scarification.