Group Basal Week 7 +10 dayswith EPI Glucose (mg/dL) ND 76.8 ± 0.78 77.7 ± 1.01   ND+E 82.6 ± 2.31 83.1 ± 3.82   PD 84.1 ± 2.04 141.1 ± 0.92 a,b 105.6 ± 1.08b a,c PD+E 82.4 ± 2.49 95.3 ± 1.14 a,b,c     Triglycerides (mmol/L) ND 0.7 ± 0.08 0.8 ± 0.04   ND+E 0.7 ± 0.05 0.80 ± 0.02   PD 0.8 ± 0.06 3.0 ± 0.05a,b 1.9 ± 0.05a,c PD+E 0.8 ± 0.06 1.3 ± 0.07a,b,c     Total colesterol (mmol/L) ND 18.5 ± 0.34 19.1 ± 0.37   ND+E 18.7 ± 0.37 19.0 ± 0.46   PD 18.8 ± 0.41 59.8 ± 0.81a,b 30.2 ± 0.94a,c PD+E 18.6 ± 0.56 25.78 ± 0.92a,b,c     HDL colesterol (mmol/L) ND 13.4 ± 0.07 13.6 ± 0.08   ND+E 13.7 ± 0.02 13.7 ± 0.07   PD 13.6 ± 0.05 8.3 ± 0.03a,b 10.6 ± 0.08a,c PD+E 13.7 ± 0.05 12.4 ± 0.03a,b,c     LDL colesterol (mmol/L) ND 4.61 ± 0.43 5.2 ± 0.37   ND+E 4.7 ± 0.53 4.9 ± 0.57   PD 4.8 ± 0.38 50.1 ± 0.62a,b 18.73 ± 0.34a,c PD+E 4.5 ± 0.56 12.8 ± 0.79a,b,c     Bloodpressure (mmHg) ND 111.9 ± 0.51 111.9 ± 0.42   ND+E 111.7 ± 0.43 112.5 ± 0.61   PD 112.3 ± 0.64 144.7 ± 0.76a,b 126.8 ± 0.74a,c PD+E 113.9 ± 0.48 119.5 ± 0.29a,b,c

Table 2: Results are presented as mean ± EEM for each group (n = 8). ND = normal diet, ND+E = normal diet concomitant with 1 mg/kg EPI during dietary induction, PD = Paigen-like diet, PD+E = Paigen-like diet concomitant with 1 mg/kg EPI during dietary induction, PD+E10 = Paigen-like diet receiving 1 mg/kg EPI for 10 days after dietary induction. ap<0.05 vs. own basal level after Student’s t test for paired samples. bp<0.05 vs. control (ND) group at the same timeline after Student’s t test for independent samples. cp<0.05 vs. Paigen-like (PD) group at 7-weeks after Student’s t test for paired samples.