Region/Country
Population |
Group |
Genotype |
Allele D
Frequency |
P-value
OR (95% CI)a |
I/I |
I/D |
D/D |
Jiangsu/China
Chinese |
Adults, lean BMI 18.5-23.9 |
566 |
452 |
82 |
0.28 |
0.019a
0.838 (0.723-0.972)a |
Adults, obese BMI ≥28 |
463 |
310 |
47 |
0.25 |
Jiangsu/China
Chinese |
Children BMI p20-50 |
204 |
194 |
53 |
0.33 |
3.1×10-4a
0.667 (0.535-0.831)a |
Children BMI p>80 |
202 |
139 |
20 |
0.25 |
Jiangsu/China
Chinese |
Non-diabetic |
1035 |
814 |
141 |
0.28 |
0.820b
1.014 (0.870-1.147)b |
T2DM |
678 |
509 |
92 |
0.27 |
Beijing/China
Chinese |
Non-diabetic |
537 |
372 |
95 |
0.28 |
0.999b
1.000 (0.876-1.141)b |
T2DM |
555 |
397 |
97 |
0.28 |
Penisular/Malaysia
Malaysian |
Non-diabetic |
331 |
241 |
57 |
0.28 |
0.741b
0.966 (0.785-1.188)b |
T2DM |
295 |
239 |
50 |
0.29 |
Tests were done with an additive model; BMI: Body Mass Index; T2DM: Type 2 Diabetes; A: Adjustment for Age and Sex; B: Adjustment for Age, Sex and BMI.