Region/Country
Population
Gender Group Genotype Allele D
Frequency
P-value
OR (95% CI)
I/I I/D D/D
Jiangsu/China
Chinese
Women Adults, lean BMI 18.5-23.9
Adults, obese BMI ≥28
342
316
291
194
54
31
0.290
0.237
0.003a
0.753 (0.625-0.906)a
Jiangsu/China
Chinese
Men Adults, lean BMI 18.5-23.9
Adults, obese BMI ≥28
224
147
162
116
27
16
0.262
0.265
0.965a
1.006 (0.782-1.293)a
Jiangsu/China
Chinese
Girls Children BMI p20-50
Children BMI p>80
91
85
92
64
32
8
0.363
0.255
0.002a
0.604 (0.437-0.835)a
Jiangsu/China
Chinese
Boys Children BMI p20-50
Children BMI p>80
113
117
102
75
21
12
0.305
0.243
0.038a
0.724 (0.533-0.983)a
Jiangsu/China
Chinese
Women Non-diabetic BMI<28
T2DM BMI<28
656
450
511
325
97
60
0.286
0.266
0.669b
0.967 (831-1.126)b
Jiangsu/China
Chinese
Men Non-diabetic BMI<28
T2DM BMI<28
379
228
303
184
44
32
0.269
0.279
0.317b
1.113 (0.902-1.372)b
Beijing/China
Chinese
Women Non-diabetic BMI<28
T2DM BMI<28
281
263
193
197
46
36
0.274
0.271
0.815b
0.977 (0.805-1.186)b
Beijing/China
Chinese
Men Non-diabetic BMI<28
T2DM BMI<28
256
292
179
200
49
61
0.286
0.291
0.833b
1.020 (0.850-1.223)b
Penisular Malaysia
Malaysian
Women Non-diabetic  BMI<28
T2DM BMI<28
142
158
102
126
24
27
0.280
0.289
0.168b
0.809 (0.599-1.094)b
Penisular Malaysia
Malaysian
Men Non-diabetic BMI<28
T2DM BMI<28
158
172
120
133
29
27
0.290
0.282
0.395b
1.135 (0.848-1.517)b
Tests were done with an additive model; BMI: Body Mass Index; T2D: Type 2 Diabetes; A: Adjustment for Age; B: Adjustment for Age and BMI
Table 3: Stratification analysis on the association of RGS9 I/D polymorphism with obesity.