|A, GTTs were performed on the mice described in the legend to Fig. 1. Groups (n=7) of C57BL/6 and S6K2-/- mice were fasted for 6 h and then administered glucose
by oral gavage (2g/kg). Blood glucose levels were measured prior to oral gavage (time zero) and 30, 60 and 120 min following treatment. B, area under the curve
(AUC) measurements performed on groups shown in A. C and D, blood insulin levels were measured prior to oral gavage of glucose (time zero) and 30, 60 and 120
mins following treatment.**P<0.01, ***P<0.001.