| TLR4 polymorphisms |
T2DM patients |
Nondiabetic subjects |
Unadjusted *P value |
Adjusted OR (95% CI) / §P value |
| Asp299Gly (A/G) |
n = 1672 |
n = 570 |
|
|
| A/A |
1531 (91.6) |
499 (87.5) |
0.005 |
1 |
| A/G |
138 (8.2) |
66 (11.6) |
|
0.68 (0.5-0.93) / 0.015 |
| G/G |
3 (0.2) |
5 (0.9) |
|
0.20 (0.05-0.82) / 0.026 |
| A |
0.96 |
0.93 |
0.002 |
|
| G |
0.04 |
0.07 |
|
|
| Dominant Model |
|
|
|
|
| A/A |
1531 (91.6) |
499 (87.5) |
0.006 |
1 |
| A/G + G/G |
141 (8.4) |
71 (12.5) |
|
0.68 (0.49-0.94) / 0.019 |
| Thr399Ile (C/T) |
n = 1683 |
n = 584 |
|
|
| C/C |
1550 (92.0) |
514 (88.0) |
0.004 |
1 |
| C/T |
131 (7.8) |
65 (11.1) |
|
0.67 (0.49 – 0.92) / 0.012 |
| T/T |
3 (0.2) |
5 (0.9) |
|
0.20 (0.05 – 0.84) / 0.027 |
| C |
0.96 |
0.94 |
0.001 |
|
| T |
0.04 |
0.06 |
|
|
| Dominant Model |
|
|
|
|
| C/C |
1550 (92.0) |
514 (88.0) |
0.004 |
1 |
| C/T + T/T |
134 (8.0) |
70 (12.0) |
|
0.65 (0.46-0.90) / 0.009 |
|
| Data are presented as number of carriers (%) or proportion. *P values were computed using χ² tests to compare T2DM patients and nondiabetic subjects. § P values adjusted for ethnicity in a logistic regression analysis. |
| Table 1: Genotype and allele distributions of TLR4 Asp299Gly and Thr399Ile polymorphisms in T2DM patients and nondiabetic subjects. |
