Inheritance model n studies n cases n controls I2(%) Pooled OR (95% CI) Sensibility analysis*             I2(%) Pooled OR (95% CI) Asp299Gly               Allelecontrast European descendent Brazilians Mexicans 7 4 2 1 3904 1700 1883 321 4348 3043 770 535 81.5 87.5 4.4 - 0.68 (0.46 – 1.00) 0.64 (0.34 – 1.22) 0.59 (0.45 – 0.79) 1.35 (0.78 – 2.32) 77.2 0.60 (0.41 – 0.88) Dominant European descendent Brazilians Mexicans 5 2 2 1 3285 1081 1883 321 2374 1069 770 535 64.6 0.0 0.0 64.6 0.89 (0.6 – 1.30) 1.16 (0.80 – 1.68) 0.62 (0.47 – 0.82) 1.36 (0.78 – 2.37) 27.9 0.68 (0.48 – 0.96) Thr399Ile               Allelecontrast European descendent Brazilians Mexicans 6 3 2 1 3581 1367 1895 319 2384 1062 784 538 81.5 90.5 54.3 - 0.65 (0.39 – 1.07) 0.65 (0.24 – 1.79) 0.46 (0.19 – 1.12) 1.13 (0.64 – 2.00) 79.3 0.56 (0.32 – 0.97) Dominant European descendent Brazilians Mexicans 5 2 2 1 3295 1081 1895 319 1971 649 784 538 59.7 0.0 50.0 - 0.85 (0.58 – 1.26) 1.14 (0.78 – 1.65) 0.60 (0.45 – 0.81) 1.13 (0.63 – 2.03) 49.6 0.66 (0.40 – 1.10)

Where significant heterogeneity was detected (I2> 50%), the DerSimonian and Laird Random Effect Model (REM) was used to calculate OR (95% CI) for each individual study and for the pooled effect; where heterogeneity was not significant, the Fixed Effect Model (FEM) was used for this calculation. * Sensibility analysis excluding the Buraczynska et al. [19] or to eliminate the heterogeneity.

Table 4: Meta-analysis pooled measures for associations between the TLR4 Asp299Gly and Thr399Ile polymorphisms and the susceptibility to T2DM.