Genotype/allele TID Controls T1D Vs Controls
LMP2 exon3 N=228 No. % N=752 No. % p  Value Odds ratio (95% C.I.)
GG (RR) 166 72.8 480 63.82 0.012 1.52 1.08-2.14
AG (HR) 57 25.00 241 32.05 0.04 0.71 0.49-0.99
AA (HH) 5 2.19 31 4.12 0.17 0.56* 0.29-1.1**
G (R) 389 85.3 1201 79.85 0.009 1.46 1.09-1.98
A (H) 67 14.7 303 20.14 0.009 0.68 0.5-0.92
LMP7 exon 2 N=225 % N=742 %      
CC (QQ) 173 76.88 516 69.54 0.03 1.45 1.02-2.1
AC (KQ) 48 21.33 191 25.74 0.18 0.78 0.53-1.13
AA (KK) 4 1.77 35 4.72 0.03 0.4 0.2-0.81
C (Q) 394 87.55 1223 82.41 0.0098 1.5 1.1-2.1
A (K) 56 12.45 261 17.58 0.0098 0.66 0.47-0.91
LMP7 Intron 6 N=230 % N=738 %      
GG 90 39.13 245 33.2 0.09 1.29 0.94-1.77
GT 106 46.08 332 44.99 0.77 1.04 0.77-1.4
TT 35 14.78 161 21.81 0.03 0.64 0.42-0.97
G 286 62.17 822 55.7 0.01 1.3 1.05-1.63
T 174 37.83 654 44.3 0.01 0.76 0.61-0.95
Haplotypes LMP2 exon 3, LMP7 exon 2, LMP7 intron 6@$      
  2N=412 % 2N=1476 %      
GCG 257 62.37 584 39.56 5.9 x10-13* 2.29 1.83-2.88
ACT 58 14.1 80 5.42 1.9 x10-8* 2.7 1.89-3.87
GCT 46 11.16 387 26.22 1.9 x10-12* 0.32 0.23-0.44
ACG 0 0 164 11.11 2.5 x10-13* 0.009** 0.001-0.07
* p value calculated using Fisher’s exact test
** Odds Ratio calculated using Woolf’s formula with Haldane’s modification
@ Haplotypes were made using SHEsis online software [19,20]
$ haplotypes showing significant differences are shown
Table 2: LMP2 and LMP7 SNPs and haplotypes in Type 1 diabetes patients compared with healthy controls.