| Genotype/allele |
TID |
Controls |
T1D Vs Controls |
| LMP2 exon3 |
N=228 No. |
% |
N=752 No. |
% |
p Value |
Odds ratio |
(95% C.I.) |
| GG (RR) |
166 |
72.8 |
480 |
63.82 |
0.012 |
1.52 |
1.08-2.14 |
| AG (HR) |
57 |
25.00 |
241 |
32.05 |
0.04 |
0.71 |
0.49-0.99 |
| AA (HH) |
5 |
2.19 |
31 |
4.12 |
0.17 |
0.56* |
0.29-1.1** |
| G (R) |
389 |
85.3 |
1201 |
79.85 |
0.009 |
1.46 |
1.09-1.98 |
| A (H) |
67 |
14.7 |
303 |
20.14 |
0.009 |
0.68 |
0.5-0.92 |
| LMP7 exon 2 |
N=225 |
% |
N=742 |
% |
|
|
|
| CC (QQ) |
173 |
76.88 |
516 |
69.54 |
0.03 |
1.45 |
1.02-2.1 |
| AC (KQ) |
48 |
21.33 |
191 |
25.74 |
0.18 |
0.78 |
0.53-1.13 |
| AA (KK) |
4 |
1.77 |
35 |
4.72 |
0.03 |
0.4 |
0.2-0.81 |
| C (Q) |
394 |
87.55 |
1223 |
82.41 |
0.0098 |
1.5 |
1.1-2.1 |
| A (K) |
56 |
12.45 |
261 |
17.58 |
0.0098 |
0.66 |
0.47-0.91 |
| LMP7 Intron 6 |
N=230 |
% |
N=738 |
% |
|
|
|
| GG |
90 |
39.13 |
245 |
33.2 |
0.09 |
1.29 |
0.94-1.77 |
| GT |
106 |
46.08 |
332 |
44.99 |
0.77 |
1.04 |
0.77-1.4 |
| TT |
35 |
14.78 |
161 |
21.81 |
0.03 |
0.64 |
0.42-0.97 |
| G |
286 |
62.17 |
822 |
55.7 |
0.01 |
1.3 |
1.05-1.63 |
| T |
174 |
37.83 |
654 |
44.3 |
0.01 |
0.76 |
0.61-0.95 |
| Haplotypes LMP2 exon 3, LMP7 exon 2, LMP7 intron 6@$ |
|
|
|
| |
2N=412 |
% |
2N=1476 |
% |
|
|
|
| GCG |
257 |
62.37 |
584 |
39.56 |
5.9 x10-13* |
2.29 |
1.83-2.88 |
| ACT |
58 |
14.1 |
80 |
5.42 |
1.9 x10-8* |
2.7 |
1.89-3.87 |
| GCT |
46 |
11.16 |
387 |
26.22 |
1.9 x10-12* |
0.32 |
0.23-0.44 |
| ACG |
0 |
0 |
164 |
11.11 |
2.5 x10-13* |
0.009** |
0.001-0.07 |
* p value calculated using Fisher’s exact test
** Odds Ratio calculated using Woolf’s formula with Haldane’s modification
@ Haplotypes were made using SHEsis online software [19,20]
$ haplotypes showing significant differences are shown |
