| Genotype/allele |
TID |
|
Controls |
|
Female T1D vs. female controls |
| LMP2 exon3 |
N=97 No. |
% |
N=199 No. |
% |
p value |
Odds ratio |
95% C.I. |
| GG |
71 |
73.19 |
117 |
58.79 |
0.016 |
1.91 |
1.09-3.39 |
| GA |
25 |
25.77 |
75 |
37.69 |
0.04 |
0.57 |
0.32-1.01 |
| AA |
1 |
1.03 |
7 |
3.52 |
0.2* |
0.4** |
0.11-1.4 |
| G |
167 |
86.08 |
309 |
77.64 |
0.015 |
1.78 |
1.09-2.96 |
| A |
27 |
13.92 |
89 |
22.36 |
0.015 |
0.56 |
0.34-0.91 |
| LMP7 exon 2 |
N=101 |
% |
N=196 |
% |
|
|
|
| CC |
79 |
78.22 |
132 |
67.35 |
0.05 |
1.74 |
0.96-3.2 |
| AC |
20 |
19.8 |
53 |
27.04 |
0.17 |
0.66 |
0.35-1.2 |
| AA |
2 |
1.98 |
11 |
5.61 |
0.12* |
0.4** |
0.15-1.08 |
| C |
178 |
88.11 |
317 |
80.87 |
0.02 |
1.75 |
1.05-3.01 |
| A |
24 |
11.88 |
75 |
19.13 |
0.02 |
0.57 |
0.33-0.95 |
| LMP7 Intron 6 |
N=96 |
% |
N=196 |
% |
|
|
|
| GG |
40 |
41.66 |
57 |
29.08 |
0.03 |
1.74 |
1.01-2.99 |
| GT |
40 |
41.66 |
95 |
48.47 |
0.27 |
0.75 |
0.45-1.28 |
| TT |
16 |
16.66 |
44 |
22.45 |
0.25 |
0.69 |
0.34-1.34 |
| G |
120 |
62.5 |
209 |
53.31 |
0.03 |
1.45 |
1.01-2.11 |
| T |
72 |
37.5 |
183 |
46.69 |
0.03 |
0.68 |
0.47-0.99 |
| Haplotypes LMP2 exon 3, LMP7 exon 2, LMP7 intron 6@$ |
|
|
|
| |
2N=170 |
% |
2N=390 |
% |
|
|
|
| GCG |
111 |
65.29 |
165 |
42.31 |
7.5 x10-6* |
2.36 |
1.61-3.45 |
| ACT |
21 |
12.35 |
34 |
8.72 |
0.24* |
1.41 |
0.79-2.51 |
| GCT |
18 |
10.59 |
81 |
20.8 |
0.002* |
0.43 |
0.25-0.74 |
| ACG |
0 |
0 |
34 |
8.72 |
4.1x10-5* |
0.03** |
0.004-0.22 |
* p value calculated using Fisher’s exact test
** Odds Ratio calculated using Woolf’s formula with Haldane’s modification
@ Haplotypes were made using SHEsis online software [19,20]
$ haplotypes showing significant differences are shown |
