| Genotype/allele |
TID Onset age ≤14 |
Control |
Age at onset ≤ 14Vs. Controls |
TIDOnset age >14 |
|
Age at onset > 14Vs. Controls |
| LMP2 exon3 |
N=99 (%) |
N=752(%) |
p Value |
Odds ratio |
95% CI |
N=117(%) |
p Value |
Oddsratio |
95% Cl |
| GG |
74
-74.75 |
480 (63.82) |
0.03 |
1.67 |
1.02-2.82 |
83
-70.94 |
0.13 |
1.38 |
0.89-2.19 |
| GA |
23
-23.2 |
241 (32.05) |
0.07 |
0.64 |
0.37-1.06 |
31
-26.49 |
0.23 |
0.76 |
0.47-1.2 |
| AA |
2
-2.02 |
31
-4.12 |
0.24* |
0.58** |
0.23-1.48 |
3
-2.56 |
0.3* |
0.7** |
0.31-1.54 |
| G |
171
-86.4 |
1201 (79.85) |
0.029 |
1.598 |
1.04-2.54 |
197
-84.19 |
0.12 |
1.34 |
0.92-2.0 |
| A |
27
-13.6 |
303 (20.14) |
0.029 |
0.625 |
0.39-0.96 |
37
-15.81 |
0.12 |
0.74 |
0.49-1.08 |
LMP7
exon 2 |
N=97 |
N=742 |
|
|
|
N=115 |
|
|
|
| CC |
75
-77.32 |
516 (69.54) |
0.11 |
1.49 |
0.89-2.59 |
88
-76.52 |
0.12 |
1.43 |
0.89-2.35 |
| AC |
21
-21.65 |
191 (25.74) |
0.38 |
0.79 |
0.45-1.35 |
24
-20.87 |
0.26 |
0.76 |
0.45-1.25 |
| AA |
1
-1.03 |
35 (4.72) |
0.06* |
0.31** |
0.09-0.99 |
3
-2.61 |
0.22* |
0.62** |
0.28-1.36 |
| C |
171
-88.14 |
1223 (82.41) |
0.045 |
1.58 |
0.99-2.62 |
200
-86.96 |
0.087 |
1.42 |
0.94-2.21 |
| A |
23
-11.86 |
261 (17.58) |
0.045 |
0.63 |
0.38-1.0 |
30
-13.04 |
0. 087 |
0.7 |
0.45-1.06 |
LMP7
Intron 6 |
N=99 |
N=738 |
|
|
|
N=118 |
|
|
|
| GG |
45
-45.45 |
245
-33.2 |
0.016 |
1.67 |
1.07-2.62 |
42
-35.59 |
0.61 |
1.11 |
0.72-1.69 |
| GT |
40
-40.4 |
332 (44.99) |
0.39 |
0.82 |
0.53-1.29 |
57
-48.3 |
0.5 |
1.14 |
0.76-1.72 |
| TT |
14
-14.14 |
161 (21.81) |
0.08 |
0.59 |
0.3-1.08 |
19
-16.1 |
0.16 |
0.69 |
0.38-1.17 |
| G |
130
-65.66 |
822
-55.7 |
0.007 |
1.52 |
1.1-2.11 |
141
-59.75 |
0.22 |
1.19 |
0.89-1.59 |
| T |
68
-34.34 |
654
-44.3 |
0.007 |
0.66 |
0.47-0.9 |
94 |
0.22
-40.25 |
0.84 |
0.62-1.12 |
| Haplotypes LMP2 exon 3,LMP7 exon 2, LMP7 intron 6@$ |
| |
2N=174 |
2N=1476 |
p Value |
Odds ratio |
95% CI |
N=210 |
p Value |
Odds ratio |
95% CI |
| GCG |
119
-68.4 |
584 (39.6) |
4.5x10-11* |
3.05 |
2.16-4.29 |
122
-58 |
2x10-5* |
1.89 |
1.41-2.54 |
| ACT |
20
-11.5 |
80 (5.42) |
0.003* |
2.14 |
1.28-3.6 |
34
-16.2 |
5.14x10-8* |
3.15 |
2.05-4.86 |
| GCT |
16
-9.2 |
387 (26.22) |
1.96x10-12* |
0.32 |
0.23-0.44 |
25
-12 |
6.85x10-7* |
0.35 |
0.23-0.54 |
| ACG |
0
0 |
164 (11.11) |
2.47x10-13* |
0.02** |
0.003-0.16 |
0
0 |
1.32x10-7* |
0.02** |
0.002-0.14 |
|
