LMP2-LMP7 haplotypes-HLA DRB1 T1D Controls      
  No. of haplotypes 2N=398 % No. of haplotypes 2N=700 % P value Odds Ratio 95% C.I.
GCG-DRB1*03:01 148 37.19 51 7.28 1.5x 10-42 9.37 6.48-13.63
GCG-DRB1*07:01 21 5.28 61 8.71 0.03 0.584 0.33-0.99
ACT-DRB1*03:01 33 8.29 9 1.28 5.9 x 10-9 6.94 3.2-16.65
ACT-DRB1*07:01 14 3.52 16 2.28 0.229 1.56 0.69-3.44
GCT-DRB1*03:01 30 7.53 18 2.57 0.0001 3.08 1.64-5.96
GCT-DRB1*07:01 3 0.75 39 5.57 0.00002* 0.148** 0.07-0.32
*p value calculated using Fisher’s exact test
**Odds Ratio calculated using Woolf’s formula with Haldane’s modification
Table 7: Simultaneous presence of predisposing and protective LMP2-LMP7 haplotypes with predisposing and protective HLA alleles.