| LMP2-LMP7 haplotypes-HLA DRB1 |
T1D |
Controls |
|
|
|
| |
No. of haplotypes 2N=398 |
% |
No. of haplotypes 2N=700 |
% |
P value |
Odds Ratio |
95% C.I. |
| GCG-DRB1*03:01 |
148 |
37.19 |
51 |
7.28 |
1.5x 10-42 |
9.37 |
6.48-13.63 |
| GCG-DRB1*07:01 |
21 |
5.28 |
61 |
8.71 |
0.03 |
0.584 |
0.33-0.99 |
| ACT-DRB1*03:01 |
33 |
8.29 |
9 |
1.28 |
5.9 x 10-9 |
6.94 |
3.2-16.65 |
| ACT-DRB1*07:01 |
14 |
3.52 |
16 |
2.28 |
0.229 |
1.56 |
0.69-3.44 |
| GCT-DRB1*03:01 |
30 |
7.53 |
18 |
2.57 |
0.0001 |
3.08 |
1.64-5.96 |
| GCT-DRB1*07:01 |
3 |
0.75 |
39 |
5.57 |
0.00002* |
0.148** |
0.07-0.32 |
*p value calculated using Fisher’s exact test
**Odds Ratio calculated using Woolf’s formula with Haldane’s modification |
