Diabetes duration 
<1 year 
14 years 
510 years 
14 years 
>20 years 

n=22 
n=69 
n=81 
n=100 
n=71 
Amylin, pM/dL, median 
26.2 
28.2 
26 
17.9 
13 
(Q1, Q3)** 
(13.4, 69.6) 
(15.8, 57.3) 
(11.4, 48.0) 
(9.9, 41.4) 
(5.8, 29.2) 
Insulin treatment, n (%)*** 
0 (0.0) 
6 (8.7) 
18 (22.2) 
38 (38.0) 
37 (52.1) 
Cardiovascular disease, n (%)* 
13 (59.1) 
24 (35.8) 
42 (52.5) 
56 (56.6) 
44 (63.8) 
Stroke, n (%) 
3 (13.6) 
14 (20.3) 
19 (23.1) 
31 (31.3) 
20 (29.4) 
Diabetic subjects are divided into three subgroups based on disease duration:<1 year; 14 years; 59 years; 1020 years and >20 years. n/total with Fisher exact test
or mean ± SD with ANOVA test or is used to describe the normal distributions and comparisons of those with insulin treatment, amylin concentration and the vascular
complications across five subgroups.
P values for the statistical significance are shown with *p<0.05; **p<0.001; ***p<0.0001 