Log10 Amylin (n = 930) Log10 Amylin (n = 930)   Model I   Model II     Estimate b  (SE) p value Estimate b  (SE) p value Diabetes +0.43 (0.19) 0.02 +0.33 (0.24) 0.16 Diabetes duration -0.17 (0.06) 0.002 -0.18 (0.06) 0.002 Insulin treatment -0.53 (0.16) 0.0008 -0.49 (0.19) 0.03 Plasma amylin was transformed to log10 (Log10 Amylin). Model I = adjusting for age, sex, ethnicity, education, ApoE4, BMI, cardiovascular disease, stroke, lengths of diabetes, creatinine (kidney function) and the lipid profile includes cholesterol, LDL and HDL. Model II = Model I plus other diabetic drugs including metformin, sulfonylureas, glitazones and meglitinide

Table 3: Multivariate regression analysis on the relationship between plasma amylin as an outcome and insulin use in diabetes