Study Subjects Intervention Relative Risk
Reduction of T2D/
mean duration
of intervention
Relative Risk
Reduction of T2D/
mean duration
of follow-up
DPS 522 individuals mean age 55±7 years, and mean BMI 31.2±4,5 kg/m2 with IGT 1. Control group: general advice about healthy lifestyle at baseline.
2. Intervention group: Individualized lifestyle intervention included 7 face-to-face counseling sessions with nutritionist during the first year and every 3 months thereafter. Intervention goals: body weight reduction of ≥5%, total fat intake <30% of energy, saturated fat intake <10% of energy, fibre intake of ≥15gr/1000kcal and moderate exercise for  ≥30/day
58%
(p<0.001)
Compared with control group /
3.2 years
42%
(p=0.0001)
Compared with control group /
a median post-intervention follow up of 4 years (7 from baseline) 38%
(p<0.001)
Compared with control group /
a median post-intervention follow up of 9 years (13 years from baseline)
CDQDPS 577 people mean age of 45±9.1 years and BMI 25.8±3.8kg/m2 with IGT 1. Control group: general advice about healthy lifestyle at baseline
2. Dietary  intervention: individual counseling+ compliance evaluation by physician/nurse every 3 months + small groups weekly for 1 month, monthly for 3 months and every 3 months thereafter. Intervention goals:  weight reduction aiming at <24 kg/m2, 55-65% of energy carbohydrate, 25-30% of energy fat and 10-15% of energy protein. Increase vegetables, decrease alcohol and sugar.
3. Exercise intervention: physical activity by at least 30 minutes of moderate activities and 20 minutes of vigorous activities daily
4. Diet+Exercise intervention: diet-plus- exercise combined intervention
33% of dietary  group
(p<0.03) 47% of exercise group
(p<0.0005) 38% diet + exercise group
(p<0.005) Compared with control group /
6 years
43% all intervention group
(p<0.01)
Compared with control group /
20 years from baseline
DPP 3234 US adults mean age of 50.6±10.7 years and mean ΒΜΙ 34±6.7 kg/m2 with IGT 1. Placebo group: general advice about healthy lifestyle at baseline.
2. Intervention group: 16 face-to-face counseling sessions with registered dietitian during the first 24 week and every 2 months thereafter. Intervention goals: ≥7% weight loss, total fat intake <25% of energy, energy reduction of 500-1000 kcal/day and 150 min or more per week of moderate-intenp physical activity
3. Metformin intervention: 850 mg twice per day
58% of lifestyle group  
(p<0.01) 31% of metformin                
(p<0.01) Compared with placebo group /
2.8 years
 
DPPOS
post-intervention ongoing observational follow-up to the DPP
2766  DPP participants mean age of 55.2±10.3 years and mean ΒΜΙ 32.7±6.6 kg/m2 all three groups of DPP were offered group-implemented lifestyle intervention with registered dietitian
metformin treatment was continued in the original metformin groupt
the original lifestyle intervention group was offered additional lifestyle support
  34% of lifestyle group 18% of metformin group
(p<0.001) Compared with placebo group /
10 years (DPP + DPPOS)
Table 1: Long-term follow-up of diabetes prevention programs.