*significant difference versus baseline

Figure 3: Effect of metformin on serum insulin. Fasting serum insulin 24.1 ± 15.3 mIU/l significantly reduced at 6 month 17.2 ± 8.8 mIU/l (p=0.012), at 9 month 13.2 ± 6.9 mIU/l (p<0.001) and at 1 year 11.6 ± 6.0 mIU/l (p<0.001); 2-h PGL serum insulin 62.6 ± 43.2 mIU/l significantly reduced at 3 month 45.1 ± 26.6 mIU/l (p=0.040), at 6 month 38.7 ± 29.0 mIU/l (p=0.026), at 9 month 26.1 ± 13.8 mIU/l (p<0.001) and at 1 year 27.6 ± 21.6 mIU/l (p<0.001); PGL= post glucose load.