Variables Baseline 3 month 6 month 9 month 1 year Fasting PG (mmol/l) 5.40 ± 0.53 5.07 ± 0.52 5.04 ± 0.40 4.88 ± 0.52 4.74 ± 0.50 p   0.029* 0.002* <0.001* <0.001* Total cholesterol (mmol/l) 5.78 ± 0.76 5.46 ± 0.94 5.11 ± 1.04 4.67 ± 0.95 4.87 ± 0.86 p   0.265 0.009* <0.001* <0.001* LDL cholesterol (mmol/l) 3.61 ± 0.76 3.32 ± 0.93 3.27 ± 1.04 2.77 ± 0.65 2.74 ± 0.94 p   0.309 0.282 0.007* 0.001* HDL cholesterol (mmol/l) 1.10 ± 0.34 1.28 ± 0.34 1.23 ± 0.28 1.20 ± 0.26 1.44 ± 0.28 p   0.114 0.214 0.403 <0.001* Triglycerides (mmol/l) 2.60 ± 1.74 2.17 ± 1.35 1.97 ± 0.90 1.55 ± 0.69 1.44 ± 0.53 p   0.347 0.083 0.004* <0.001* Systolic BP (mm Hg) 131 ± 18 128 ± 15 125 ± 11 121 ± 15 119 ± 12 p   0.426 0.057 0.008* <0.001* Diastolic BP (mm Hg) 85 ± 11 84 ± 9 81 ± 8 78 ± 8 76 ± 6 p   0.711 0.072 <0.001* <0.001* * significant difference versus baseline.

Table 3: Effect of metformin treatment on Fasting PG, Total cholesterol, LDL cholesterol, HDL cholesterol, Triglycerides, Systolic BP, Diastolic BP at 3, 6, 9 month and at 1 year; PG= plasma glucose; LDL= low density lipoprotein; HDL= high density lipoprotein; BP= blood pressure