All Patients with genotype or allele ( [n]) Extremely obese patients with genotype or allele ( [n])  
Controls (n = 230) Extremely obese patients (n = 335) without T2DM   (n = 134) with T2DM   (n = 201)
M235T          
MM 28.70  [66] 29.55  [99] 32.84  [44] 27.36  [55]  
MT 52.17 [120] 58.81 [197] 52.99 [71] 62.69 [126]  
TT 19.13 [44] 11.64 [39] 14.18 [19] 9.95 [20]  
  p value  0.04265a 0.42951b 0.01631c 0.18865d
Allel M 54.78 [252] 58.96 [395] 59.33 [159] 58.71 [236]  
Allel T 45.22 [208] 41.04 [275] 40.67 [109] 41.29 [166]
  p value  0.164a 0.233 b 0.246c 0.873d
T174M          
TT 73.91 [170] 70.45 [236] 72.39 [97] 69.15 [139]  
TM 25.22 [58] 28.06 [94] 26.87 [36] 28.86 [58]  
MM 0.87 [2] 1.49 [5] 0.75 [1] 1.99 [4]  
  p value  0.602a 0.912 b 0.418c 0.58680 d
Allel T 86.52 [398] 84.48 [566] 85.82 [230] 83.58 [336]  
Allel M 13.48 [62] 15.52 [104] 14.18 [38] 16.42 [66]
  p value  0.340a 0.791 b 0.226c 0.433 d
p values indicate differences in genotype and allele frequencies between groups: acontrols vs. all cases; bcontrols vs. cases without T2DM; ccontrols vs. cases with T2DM; dcases without T2DM vs. cases with T2DM AGT: Angiotensinogen; T2DM: Type 2 Diabetes Mellitus
Table 2: Genotypes of the angiotensinogen (AGT) gene M235T and T174M polymorphisms and alleles in extremely obese patients and controls.