| |
All Patients with genotype or allele ( [n]) |
Extremely obese patients with genotype or allele ( [n]) |
|
| Controls (n = 230) |
Extremely obese patients (n = 335) |
without T2DM (n = 134) |
with T2DM (n = 201) |
| M235T |
|
|
|
|
|
| MM |
28.70 [66] |
29.55 [99] |
32.84 [44] |
27.36 [55] |
|
| MT |
52.17 [120] |
58.81 [197] |
52.99 [71] |
62.69 [126] |
|
| TT |
19.13 [44] |
11.64 [39] |
14.18 [19] |
9.95 [20] |
|
| |
p value |
0.04265a |
0.42951b |
0.01631c |
0.18865d |
| Allel M |
54.78 [252] |
58.96 [395] |
59.33 [159] |
58.71 [236] |
|
| Allel T |
45.22 [208] |
41.04 [275] |
40.67 [109] |
41.29 [166] |
| |
p value |
0.164a |
0.233 b |
0.246c |
0.873d |
| T174M |
|
|
|
|
|
| TT |
73.91 [170] |
70.45 [236] |
72.39 [97] |
69.15 [139] |
|
| TM |
25.22 [58] |
28.06 [94] |
26.87 [36] |
28.86 [58] |
|
| MM |
0.87 [2] |
1.49 [5] |
0.75 [1] |
1.99 [4] |
|
| |
p value |
0.602a |
0.912 b |
0.418c |
0.58680 d |
| Allel T |
86.52 [398] |
84.48 [566] |
85.82 [230] |
83.58 [336] |
|
| Allel M |
13.48 [62] |
15.52 [104] |
14.18 [38] |
16.42 [66] |
| |
p value |
0.340a |
0.791 b |
0.226c |
0.433 d |
|
| p values indicate differences in genotype and allele frequencies between groups: acontrols vs. all cases; bcontrols vs. cases without T2DM; ccontrols vs. cases with T2DM; dcases without T2DM vs. cases with T2DM AGT: Angiotensinogen; T2DM: Type 2 Diabetes Mellitus |
| Table 2: Genotypes of the angiotensinogen (AGT) gene M235T and T174M polymorphisms and alleles in extremely obese patients and controls. |
