| |
|
|
Control subjects |
Extremely obese patients |
| Haplotype |
M235T variant |
T174M variant |
(n = 230) |
all cases
(n = 335) |
cases without T2DM (n = 134) |
cases with T2DM (n = 201) |
| |
|
|
n |
% |
n |
% |
n |
% |
n |
% |
| Hap 1 |
M |
T |
250 |
54.35 |
387 |
57.76 |
157 |
58.58 |
230 |
57.21 |
| Hap 2 |
T |
T |
148 |
32.17 |
179 |
26.72 |
73 |
27.24 |
106 |
26.37 |
| Hap 3 |
T |
M |
60 |
13.04 |
96 |
14.33 |
36 |
13.43 |
60 |
14.93 |
| Hap 4 |
M |
M |
2 |
0.44 |
8 |
1.19 |
2 |
0.75 |
6 |
1.49 |
| p value |
|
|
0.144a |
0.521b |
0.118c |
0.815d |
|
Hap4 were excluded from analyses
p values indicate differences in haplotype frequencies between groups: acontrols vs. all cases; bcontrols vs. cases without T2DM; ccontrols vs. cases with T2DM; dcases without T2DM vs. cases with T2DM
T: Threonine; M: Methionine; T2DM: Type 2 Diabetes Mellitus |
| Table 4: AGT haplotypes and their frequencies in controls and study groups. |
