| |
Total |
HAI (z score) |
WBAR (%) |
| |
Low (<1.46) |
High (≥1.46) |
Low (<8.75) |
High (≥8.75) |
| n (male/female) |
70 (24/46) |
35 (13/22) |
35 (11/24) |
35 (15/20) |
35 (9/26) |
| Age (years) |
76.6 ± 5.6 |
75.5 ± 5.0 |
77.6 ± 6.0 |
74.3 ± 4.3 |
78.8 ± 5.9**** |
| Duration of diabetes (years) |
20.6 ± 8.9 |
19.3 ± 9.4 |
21.9± 8.3 |
18.6 ± 8.2 |
22.6 ± 9.2# |
| Education years |
9.59 ± 1.80 |
10.0 ± 1.9 |
9.0 ± 1.4* |
10.1 ± 1.8 |
9.0 ± 1.6* |
| Smoking (-/+) |
64/6 |
34/1 |
30/5 |
34/1 |
30/5# |
| Treatment (Diet/OHA/Ins) |
14/45/11 |
5/26/4 |
9/19/7 |
7/25/3 |
7/20/8 |
| Body mass index (kg/m2) |
23.4 ± 4.4 |
23.3 ± 3.8 |
23.6 ± 5.0 |
22.5± 3.6 |
24.3 ± 5.0# |
| Apo E ε4 (-/+) |
61/9 |
30/5 |
31/4 |
31/4 |
30/5 |
| Systolic BP (mmHg) |
134.8 ± 17.6 |
136.3 ± 16.0 |
133.3 ± 19.0 |
134.5 ± 15.1 |
135.1 ± 20.0 |
| Diastolic BP (mmHg) |
71.6 ± 11.1 |
74.0 ± 9.8 |
69.2 ± 11.9# |
72.8 ± 9.0 |
70.5 ± 12.9 |
| HDL-cholesterol (mg/dL) |
55.9 ± 15.5 |
55.3 ± 15.3 |
56.4 ± 16.0 |
57.8 ± 15.7 |
54.0 ±15.4 |
| Triglycerides (mg/dL) |
113.2 ± 55.7 |
112.4 ± 60.9 |
114.0 ± 50.9 |
95.5 ± 42.2 |
130.9 ± 62.2* |
| LDL-cholesterol (mg/dL) |
103.2 ±25.4 |
103.3 ± 22.4 |
105.1 ± 31.3 |
101.2 ± 23.6 |
105.2 ± 27.2 |
| LDL-cholesterol (mg/dL) |
103.2 ±25.4 |
103.3 ± 22.4 |
105.1 ± 31.3 |
101.2 ± 23.6 |
105.2 ± 27.2 |
| FBG (mg/dL) |
133.2 ± 30.8 |
136.2 ± 31.9 |
130.3 ± 29.7 |
134.2 ± 29.4 |
132.3 ± 32.5 |
| HbA1c (%) |
6.96 ±0.71 |
6.93 ± 0.67 |
6.98 ± 0.76 |
6.96± 0.75 |
6.95 ± 0.68 |
| Fasting c-peptide (ng/mL) |
2.08 ± 1.15 |
2.30 ± 1.21 |
1.85 ± 1.05 |
2.04 ± 1.16 |
2.11 ± 1.15 |
| hs-CRP (mg/L) |
1.06 ± 1.44 |
1.01 ± 1.52 |
1.11 ± 1.37 |
0.89 ± 1.31 |
1.23 ± 1.55# |
| ICAM-1 (μg/L) |
218.1 ±80.8 |
209.2 ± 60.0 |
227.0 ± 97.3 |
190.8 ± 57.0 |
245.4 ± 91.9*** |
| TNF-α (pg/mL) |
1.96 ± 0.96 |
1.99 ± 0.90 |
1.93 ± 1.02 |
1.58 ± 0.73 |
2.34 ± 1.01**** |
| IL-6 (pg/mL) |
1.78 ± 1.57 |
1.64 ± 1.48 |
1.93 ± 1.67 |
1.49 ± 1.52 |
2.08 ± 1.59* |
| Adiponectin (μg/mL) |
16.82 ± 11.41 |
16.51± 11.38 |
17.13 ± 11.59 |
16.57 ± 11.00 |
17.08 ± 11.96 |
| Uric acid (mg/dL) |
5.60 ± 1.45 |
6.01 ± 1.30 |
5.17 ± 1.48* |
5.38 ± 1.15 |
5.82± 1.70 |
| Creatinine (mg/dL) |
0.84 ±0.26 |
0.87 ± 0.17 |
0.91 ± 0.32 |
0.70 ± 0.15 |
1.01 ± 0.26**** |
| Cystatin C (mg/L) |
1.11 ± 0.40 |
1.14 ± 0.43 |
1.08 ± 0.37 |
0.98 ± 0.22 |
1.25 ± 0.49*** |
| eGFRcys (ml/min/1.73m2) |
64.8 ±22.8 |
63.0 ± 20.6 |
66.6 ± 24.9 |
71.6 ± 17.1 |
58.0 ± 25.7* |
| eGFRcys<60ml/min/1.73m2 (-/+) |
38/32 |
18/17 |
20/15 |
25/10 |
13/22*** |
| ACR (mg/g creatinine) |
54.5 ± 84.7 |
40.5 ± 59.8 |
68.6 ± 102.9* |
37.4 ± 50.1 |
71.7 ± 107.0# |
| Albuminuria (-/+) |
41/29 |
20/8 |
14/21*** |
25/10 |
16/19* |
| Cognitive test scores |
|
|
|
|
|
| MMSE |
25.14 ±3.21 |
25.60± 2.58 |
24.69± 3.72 |
25.34 ± 2.82 |
24.94 ± 3.60 |
| Immediate word recall |
6.44 ±1.54 |
6.81 ± 1.30 |
6.07 ± 1.69* |
7.03 ± 1.06 |
5.85 ± 1.72*** |
| Delayed word recall |
6.47 ±2.41 |
7.14 ± 1.79 |
5.80 ± 2.77* |
7.29 ± 1.95 |
5.66 ± 2.58*** |
| DSST |
32.62 ±11.10 |
35.86 ± 12.25 |
29.18 ± 8.66*** |
36.77 ± 11.56 |
28.21 ± 8.79* |
| Stroop |
18.51 ±9.97 |
16.62 ± 7.85 |
20.47 ± 11.56 |
16.11 ± 7.79 |
20.99 ± 11.40* |
| MR findings |
|
|
|
|
|
| SBI (0/1-3/3<) |
30/25/15 |
14/14/7 |
16/11/8 |
20-09-2006 |
10/16/9# |
| PWMLs (0/1/2/3) |
26/31/11/2 |
14/15/6/0 |
12/16/5/2 |
19/12/4/0 |
7/19/7/2* |
| SWMLs (0/1/2/3) |
20/36/12/2 |
12/17/6/0 |
8/19/6/2 |
14/17/4/0 |
6/19/8/2# |
|
