Univariate analysis Multivariate analysis
Correlation coefficient p value Standardized β coefficient (SE) p value
HAI     r2=0.395, p<0.001
Age (years) 0.438 0.000 0.340 (0.017) 0.001
Albuminuria 0.347 0.003 0.213 (0.203) 0.044
sICAM-1 (μg/mL) 0.335 0.005 0.214 (0.001) 0.048
DBP (mmHg) -0.304 0.011 -0.226 (0.009) 0.030
Smoking 0.249 0.037 0.128 (0.349) 0.212
WBAR     r2=0.510, p<0.001
Age (years) 0.516 0.000 0.402 (0.062) 0.002
 SWMLs grade 0.411 0.000 0.269 (0.478) 0.045
 Log IL-6 (pg/mL) 0.381 0.001 0.043 (1.272) 0.759
 eGFRcys<60ml/min/1.73m2 0.404 0.001 0.002 (0.749) 0.990
 PWMLs grade 0.384 0.001 0.079 (0.462) 0.558
 sICAM-1 (μg/mL) 0.348 0.003 0.086 (0.004) 0.425
Log TNF-α (pg/mL) 0.442 0.009 0.163 (1.762) 0.239
 SBI 0.310 0.009 -0.141 (0.504) 0.321
 Albuminuria 0.280 0.019 0.067 (0.625) 0.551
Duration of diabetes (years) 0.271 0.023 0.112 (0.035) 0.333
 Log hs-CRP(mg/L) 0.271 0.024 0.071 (0.768) 0.580
 Treatment modality 0.251 0.036 0.025 (0.523) 0.823
Table 2: Factors associated with hippocampal atrophy index (HAI) and whole brain atrophy rate (WBAR).