| |
11β-hydroxysteroid dehydrogenase type 1 |
11β-hydroxysteroid dehydrogenase type 2 |
| Chromosomal location |
1q32.2 |
16q22 |
| Gene and size |
HSD11B1
30kb, 6 exons |
HSD11B2
6.2kb, 5 exons |
| Protein size |
292 amino acids, 34kDa |
405 amino acids, 444kDa |
| Enzyme reactions |
Bi-directional:
In vivo: oxoreductase
In vitro: dehydrogenase |
Dehydrogenase |
| Action |
Converts inactive GC into active GC |
Converts active GC into inactive GC |
| Co-factor(s) |
Oxoreductase: NADPH
Dehydrogenase: NADP+ |
NAD+ |
| Distribution |
Mainly expressed in the liver, lungs, pituitary,
brains and adipose tissues |
Mainly expressed in the kidney, colon,salivary gland and placenta |
| Substrate affinity |
Low affinity (Km in μM)
Corticosterone 1.8μM Cortisol 17μM
11-dehydrocorticosterone ~0.12μ |
High affinity (Km in μM)
Corticosterone 5nM Cortisol 50μM
11-dehydrocorticosterone negligible |
| Function (s) |
Regulation of intracellular active GC level |
Protection of mineralocorticoid binding of active GC receptors from |
