Treatment Treatment period Route of administration Compound Concentration (mg/kg) 11β-HSD1 activities 11β-HSD2 activities Refs.
Tissues Tissues
Liver Kidney AM QF SAT VAT Liver Kidney AM QF SAT VAT
Leanrats 24 hours IP GA 50 * * * * * * [38]
7days Oral GA 50 * * * [43]
24 hours IP GE 50 * ** ** [42]
High-fat diet
(animal-based)
28-days Oral GA 100 * ** ** ** * ** [53]
High-fat diet
(plant-based)
28-days Oral GA 100 * * [54]
High-sucrosediet 28-days Oral GA 100 ** * * * ** ** * ** * * [39]
High-fat+high- sucrose+stress 28-days Oral GA 100 * * Not available Not available [41]
Adrenalectomized 28-days Oral GA 100 * * * * * [40]
Table 2: 11β-hydroxysteroid dehydrogenase type 1 and 2 (11β -HSD1 and 2) activities in different tissues under different physiological conditions (IP- intraperitoneal injection; AM: Abdominal muscle; QF- quadriceps femoris; SAT- subcutaneous adipose tissues; VAT- visceral adipose tissues; * and ** indicate significant changes with p-value of 0.05 and 0.01 respectively).